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La bibliothèque des étudiants en santé

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9415 ressources

  • Article libreArticleEn anglais

    How do countries select and use digital global goods in emergency settings? Lessons learned from the DHIS2 COVID-19 data management experiences in Burkina Faso, Mali and Suriname

    Lauren Gilliss, Caitlin Madevu-Matson, Colleen Boyle, Derek Kunaka, Madina Kouyate, Rahim Kebe, Vijay Sewradj, Stephanie Watson-Grant

    AbstractDigital health global goods software are accessible, adaptable and scalable tools that can contribute to strengthened health data management and service delivery. This study explored how government stakeholders in three countries (Burkina Faso, Mali and Suriname) selected digital health global goods for COVID-19 vaccine response efforts, including whether and how these digital tools were adapted and scaled, challenges that were encountered and lessons learned from the experience. Primary data were collected through 28 purposively sampled, semi-structured key informant interviews between March and May 2023 with national- and regional-level stakeholders involved in COVID-19 vaccination response efforts. Qualitative data were analyzed deductively and inductively using thematic coding. Ministries of health in each country selected District Health Information Software 2 (DHIS2) as a COVID-19 vaccine tracking information system, but the system selection and configuration process differed. Key factors that most influenced the use of DHIS2 included country familiarity with the tool, urgent demand for real-time data and partner influence. Supportive supervision and reinforcement of data quality contributed to the effective use of DHIS2. Contextual factors, including adequate infrastructure and funding, posed challenges in system use. Experience using DHIS2 during the COVID-19 pandemic has led to plans for its expanded use in other health areas. Based on the findings, the authors recommend ministries of health utilize familiar global goods systems during health emergency periods, donors coordinate to streamline future digital system investments and technical and financial partners support countries to invest in the enabling environment for global goods systems to effectively and sustainably operate. Abrégé Les logiciels de produits mondiaux de santé numérique sont des outils accessibles, adaptables et évolutifs qui peuvent contribuer à renforcer la gestion des données

    ImmunologiePharmacognosie, phytothérapie et médecine traditionnelleSanté publiqueLicence : https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
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  • Article libreArticleEn anglais

    How do free healthcare policies impact utilization of maternal and child health services in fragile settings? Evidence from a controlled interrupted time series analysis in Burkina Faso

    Thit Thit Aye, Hoa Thi Nguyen, Laurène Petitfour, Valéry Ridde, Felix Amberg, Emmanuel Bonnet, Mariam Seynou, Joël Arthur Kiendrébéogo, Manuela De Allegri

    AbstractBurkina Faso has implemented a nationwide free healthcare policy (gratuité) for pregnant and lactating women and children under 5 years since April 2016. Studies have shown that free healthcare policies can increase healthcare service use. However, the emerging coronavirus disease 2019 pandemic, escalating insecurity and the political situation in recent years might have affected the implementation of such policies. No studies have looked at whether the gratuité maintained high service use under such changing circumstances. Our study aimed to assess the effects of gratuité on the utilization of facility-based delivery and curative care of children under 5 years in light of this changing context. We employed a controlled interrupted time series analysis using data from the Health Management Information System and annual statistical reports of 2560 primary health facilities from January 2013 to December 2021. We focused on facility-based deliveries and curative care for children under 5 years, with antenatal care and curative care for children over 5 years as non-equivalent controls. We employed segmented regression with the generalized least square model, accounting for autocorrelation and monthly seasonality. The monthly utilization rate among children under 5 years compared to those above 5 years (controls) immediately increased by 111.19 visits per 1000 children (95% CI: 91.12, 131.26) due to the gratuité. This immediate effect declined afterwards with a monthly change of 0.93 per 1000 children (95% CI: −1.57, −0.29). We found no significant effects, both immediate and long-term, on the use of maternal care services attributable to the gratuité. Our findings suggest that free healthcare policies can be instrumental in improving healthcare, yet more comprehensive strategies are needed to maintain healthcare utilization. Our findings reflect the overall situation in the country, while localized research is needed to understand the effect of insecurity and th

    PédiatrieGynécologie-obstétriqueSanté publiqueLicence : https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
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  • Article libreArticleEn anglais

    How do high ambient temperatures affect infant feeding practices? A prospective cohort study of postpartum women in Bobo-Dioulasso, Burkina Faso

    Chérie Part, Véronique Filippi, Jenny A Cresswell, Rasmané Ganaba, Shakoor Hajat, Britt Nakstad, Nathalie Roos, Kadidiatou Kadio, Matthew Chersich, Adelaide Lusambili, Seni Kouanda, Sari Kovats

    ObjectiveTo examine the effects of high ambient temperature on infant feeding practices and childcare.DesignSecondary analysis of quantitative data from a prospective cohort study.SettingCommunity-based interviews in the commune of Bobo-Dioulasso, Burkina Faso. Exclusive breastfeeding is not widely practised in Burkina Faso.Participants866 women (1:1 urban:rural) were interviewed over 12 months. Participants were interviewed at three time points: cohort entry (when between 20 weeks’ gestation and 22 weeks’ postpartum), three and nine months thereafter. Retention at nine-month follow-up was 90%. Our secondary analysis focused on postpartum women (n=857).ExposureDaily mean temperature (°C) measured at one weather station in Bobo-Dioulasso. Meteorological data were obtained from publicly available archives (TuTiempo.net).Primary outcome measuresSelf-reported time spent breastfeeding (minutes/day), exclusive breastfeeding of infants under 6 months (no fluids other than breast milk provided in past 24 hours), supplementary feeding of infants aged 6–12 months (any fluid other than breast milk provided in past 24 hours), time spent caring for children (minutes/day).ResultsThe population experienced year-round high temperatures (daily mean temperature range=22.6°C–33.7°C). Breastfeeding decreased by 2.3 minutes/day (95% CI -4.6 to 0.04, p=0.05), and childcare increased by 0.6 minutes/day (0.06 to 1.2, p=0.03), per 1°C increase in same-day mean temperature. Temperature interacted with infant age to affect breastfeeding duration (p=0.02), with a stronger (negative) association between temperature and breastfeeding as infants aged (0–57 weeks). Odds of exclusive breastfeeding very young infants (0–3 months) tended to decrease as temperature increased (OR=0.88, 0.75 to 1.02, p=0.09). There was no association between temperature and exclusive breastfeeding at 3–6 months or supplementary feeding (6–12 months).ConclusionsWomen spent considerably less time breastfeeding (~25 minute

    Biostatistiques et épidémiologieImmunologieMaladies infectieuses et tropicalesLicence : https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original w
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  • Article libreArticleEn anglais

    How do plant demographic and ecological traits combined with social dynamics and human traits affect woody plant selection for medicinal uses in Benin (West Africa)?

    Carlos Cédric Ahoyo, Thierry Dèhouegnon Houéhanou, Alain Sèakpo Yaoitcha, Bénédicte Perpétue Akpi, Armand Natta, Marcel Romuald Benjamin Houinato

    BackgroundSeveral hypotheses have been used in ethnobotany to explain the plant’s selection criteria by people for their daily needs. Thus, it is important to assess synergy and complementarity among them, especially, those concerning the plant use value, social dynamics and human traits. The study aims to (i) highlight people’s socio-economic factors, and plant ecological traits that affect the plant use-availability dynamic (PUD); and (ii) assess the available species diversity effect on ethno-medicinal knowledge diversity in Benin.MethodsEthnobotanical interviews were carried out to quantify the importance of local species in different ecological zones of Benin with 590 traditional medicine actors. Vegetation surveys were done to assess species availability within 337 plots of 50 m x 40 m or 60 m x 30 m, depending on the climatic zone, for a total of 61.6 ha, established in 15 forests distributed within the 10 phytodistricts of Benin. The plant use availability hypothesis was quantified as a dynamic link between species use value and availability (PUD). A general and mixed linear models were used to assess the significance of each factor’s effect on PUD. Pearson correlation test was applied on Shannon diversity index considering inventoried species in the field and those which were cited by people, for the available species diversity effect on ethno-medicinal knowledge diversity assessment.ResultsA hundred and twenty woody medicinal plants, mostly trees (68.33%), were sampled. Growth form and its interaction with phytodistrict have a significant effect (p: 0.005) on PUD. The less available trees were the most used in the phytodistricts 3, 4, 8 and 10. PUD varies significantly according to social factors (p: 0.007). Ethnicity, age and main activity were the most quoted social factors which influenced the PUD. Ethnicity and age have various effects considering the phytodistricts. Moreover, the influence of age changes following the main activity. Plant selection di

    Biostatistiques et épidémiologiePharmacognosie, phytothérapie et médecine traditionnelleSanté publiqueLicence : Open Access http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/publicdomain/zero/1.0/ This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as
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  • Article libreArticleEn anglais

    How does community health feature in Global Financing Facility planning documents to support reproductive, maternal, newborn, child and adolescent health and nutrition (RMNAH-N)? insights from six francophone West African countries

    Joël Arthur Kiendrébéogo, Orokia Sory, Issa Kaboré, Yamba Kafando, Rosie Steege, Asha S. George, Meghan Bruce Kumar

    ABSTRACTBackgroundCommunity health is key for improving Reproductive, Maternal, Newborn, Child, and Adolescent Health and Nutrition (RMNCAH-N). However, how community health supports integrated RMNCAH-N service delivery in francophone West Africa is under-researched.ObjectiveWe examined how six francophone West African countries (Burkina Faso, Côte d’Ivoire, Guinea, Mali, Niger, and Senegal) support community health through the Global Financing Facility for Women, Children and Adolescents (GFF).MethodsWe conducted a content analysis on Investment Cases and Project Appraisal Documents from selected countries, and set out the scope of the analysis and the key search terms. We applied an iterative hybrid inductive-deductive approach to identify themes for data coding and extraction. The extracted data were compared within and across countries and further grouped into meaningful categories.ResultsIn country documents, there is a commitment to community health, with significant attention paid to various cadres of community health workers (CHWs) who undertake a range of preventive, promotive and curative roles across RMNCAH-N spectrum. While CHWs renumeration is mentioned, it varies considerably. Most community health indicators focus on CHWs’ deliverables, with few related to governance and civil registration. Challenges in implementing community health include poor leadership and governance and resource shortages resulting in low CHWs performance and service utilization. While some countries invest significantly in training CHWs, structural reforms and broader community engagement are lacking.ConclusionsThere is an opportunity to better prioritize and streamline community health interventions, including integrating them into health system planning and budgeting, to fully harness their potential to improve RMNCAH-N. PAPER CONTEXT Main findings: Although community health is a key component of the Investment Cases and the Project Appraisal Documents of most of the six fran

    PédiatrieGynécologie-obstétriqueSanté publiqueLicence : http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this a
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  • Article libreArticleEn anglais

    How does explicit knowledge inform policy shaping? The case of Burkina Faso’s national social protection policy

    In 2009, Burkina Faso embarked on a process leading to the development of a national social protection policy (politique nationale de protection sociale–PNPS) in 2012. The objective of this study was to analyze the circumstances under which explicit knowledge was used to inform the process of emergence and formulation PNPS. The term explicit knowledge excludes tacit and experiential knowledge, taking into account research data, grey literature, and monitoring data. Court and Young’s conceptual framework was adapted by integrating concepts from political science, such as Kingdon’s Multiple Streams framework. Discursive and documentary data were collected from 30 respondents from national and international institutions. Thematic analysis guided the data processing. Results showed that use of peer-reviewed academic research was not explicitly mentioned by respondents, in contrast to other types of knowledge, such as national statistical data, reports on government program evaluations, and reports on studies by international institutions and NGOs, also called technical and financial partners (TFPs). The emergence phase was more informed by grey literature and monitoring data. In this phase, national actors deepened and increased their knowledge (conceptual use) on the importance and challenges of social protection. The role of explicit knowledge in the formulation phase was nuanced. The actors’ thinking was little guided by the question of whether the solutions had the capacity to solve the problem in the Burkina Faso context. Choices were based very little on analysis of strategies (effectiveness, equity, unintended effects) and their applicability (cost, acceptability, feasibility). This way of working was due in part to actors’ limited knowledge on social protection and the lack of government guidance on strategic choices. Strategic use was clearly identified. It involved citing knowledge (reports on studies conducted by TFPs) to justify the utility and feasibility o

    Biologie cellulaire et moléculaireGénétiqueSanté publiqueLicence : Creative Commons Attribution License This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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  • Article libreArticleEn anglais

    How does fresh food prescribing fit into the social service landscape? A qualitative study in Ontario, Canada

    Laura Jane Brubacher, Matthew Little, Abby Richter, Warren Dodd

    AbstractIntroduction:Food prescription programs are part of the broader social prescribing movement as an approach to address food insecurity and suboptimal diet in health care settings. These programs exist amid other social services, including income-based supports and food assistance programs; however, evaluations of the interactions between these programs and pre-existing services and supports are limited. This study was embedded within a larger evaluation of the 52-week Fresh Food Prescription (FFRx) program (April 2021–October 2022); the objective of this study was to examine how program participation influenced individuals’ interactions with existing income-based supports and food assistance programs.Methods:This study was conducted in Guelph, Ontario, Canada. One-to-one (n=23) and follow-up (n=10) interviews were conducted to explore participants’ experiences with the program. Qualitative data were analyzed thematically using a constant comparative analysis. Results:Participants described their experience with FFRx in relation to existing income-based supports and food assistance programs. FFRx reportedly extended income support further to cover living expenses, allowed participants to divert income to other necessities, and reduced the sacrifices required to meet basic needs. FFRx lessened the frequency of accessing other food assistance programs. Aspects of FFRx’s design (e.g. food delivery) shaped participant preferences in favour of FFRx over other food supports.Conclusion:As food prescribing and other social prescribing programs continue to expand, there is a need to evaluate how these initiatives interact with pre-existing services and supports and shape the broader social service landscape.

    Licence : This work is licensed under a Creative Commons Attribution 4.0 International License
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  • Article libreArticleEn anglais

    How Does Gender Affect Sustainable Intensification of Cereal Production in the West African Sahel? Evidence from Burkina Faso

    Veronique Theriault, Melinda Smale, Hamza Haider

    Highlights•We examine gender differentials in technology adoption on individually managed cereal plots.•Female plot managers are less likely to adopt yield-enhancing and soil-restoring strategy sets than male plot managers.•The socio-cultural context and economic attributes of the technology set affect incentives to adopt.•We demonstrate that plot manager characteristics do influence adoption decisions.•Household resources affect male and female plot managers differently. SummaryBetter understanding of gender differences in the adoption of agricultural intensification strategies is crucial for designing effective policies to close the gender gap while sustainably enhancing farm productivity. We examine gender differences in adoption rates, likelihood and determinants of adopting strategy sets that enhance yields, protect crops, and restore soils in the West African Sahel, based on analysis of cereal production in Burkina Faso. Applying a multivariate probit model to a nationally representative household panel, we exploit the individual plot as unit of analysis and control for plot manager characteristics along with other covariates. Reflecting the socio-cultural context of farming combined with the economic attributes of inputs, we find that female managers of individual cereal fields are less likely than their male counterparts to adopt yield-enhancing and soil-restoring strategies, although no differential is apparent for yield-protecting strategies. More broadly, gender-disaggregated regressions demonstrate that adoption determinants differ by gender. Plot manager characteristics, including age, marital status, and access to credit or extension services do influence adoption decisions. Furthermore, household resources influence the probability of adopting intensification strategy sets differently by gender of the plot manager. Variables expressing the availability of household labor strongly influence the adoption of soil-restoring strategies by female plot manag

    Pharmacognosie, phytothérapie et médecine traditionnelleSanté publiqueLicence : This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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  • Article libreArticleEn anglais

    How does hospital organisation influence the use of caesarean sections in low- and middle-income countries? A cross-sectional survey in Argentina, Burkina Faso, Thailand and Vietnam for the QUALI-DEC project

    Camille Etcheverry, Ana Pilar Betrán, Myriam de Loenzien, Michael Robson, Charles Kaboré, Pisake Lumbiganon, Guillermo Carroli, Quoc Nhu Hung Mac, Celina Gialdini, Alexandre Dumont

    BackgroundImproving the understanding of non-clinical factors that lead to the increasing caesarean section (CS) rates in many low- and middle-income countries is currently necessary to meet the challenge of implementing effective interventions in hospitals to reverse the trend. The objective of this study was to study the influence of organizational factors on the CS use in Argentina, Vietnam, Thailand and Burkina Faso. MethodsA cross-sectional hospital-based postpartum survey was conducted in 32 hospitals (8 per country). We selected women with no potential medical need for CS among a random sample of women who delivered at each of the participating facilities during the data collection period. We used multilevel multivariable logistic regression to analyse the association between CS use and organizational factors, adjusted on women’s characteristics. ResultsA total of 2,092 low-risk women who had given birth in the participating hospitals were included. The overall CS rate was 24.1%, including 4.9% of pre-labour CS and 19.3% of intra-partum CS. Pre-labour CS was significantly associated with a 24-hour anaesthetist dedicated to the delivery ward (ORa = 3.70 [1.41; 9.72]) and with the possibility to have an individual room during labour and delivery (ORa = 0.28 [0.09; 0.87]). Intra-partum CS was significantly associated with a higher bed occupancy level (ORa = 1.45 [1.09; 1.93]): intrapartum CS rate would increase of 6.3% points if the average number of births per delivery bed per day increased by 10%. ConclusionOur results suggest that organisational norms and convenience associated with inadequate use of favourable resources, as well as the lack of privacy favouring women’s preference for CS, and the excessive workload of healthcare providers drive the CS overuse in these hospitals. It is also crucial to enhance human and physical resources in delivery rooms and the organisation of intrapartum care to improve the birth experience and the working environment for t

    Biostatistiques et épidémiologieSanté publiqueLicence : Open Access http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/publicdomain/zero/1.0/ This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as
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  • Article libreArticleEn anglais

    How does malaria in pregnancy impact malaria risk in infants?

    Prasanna Jagannathan

    Malaria in pregnancy not only exerts profound negative consequences on the health of the mother and developing fetus, but may also alter the risk of malaria during infancy. Although mechanisms driving this altered risk remain unclear, in utero exposure to malaria antigens may impact the development of fetal and infant innate immunity. In an article in BMC Medicine, Natama et al. describe an ambitious analysis of basal and TLR-stimulated cord blood responses among a birth cohort in Burkina Faso. Basal levels of several cytokines, chemokines, and growth factors were shown to be significantly lower in cord blood with histopathologic evidence of placental malaria. Additionally, following TLR7/8 stimulation, samples obtained from infants of mothers with placental malaria were hyper-responsive compared to those without evidence of prenatal malaria exposure. Furthermore, several responses impacted by placental malaria were associated with differential malaria risk in infancy. Understanding how malaria in pregnancy shapes immune responses in infants will provide critical insight into the rational design of malaria control strategies during pregnancy, including intermittent preventative treatment in pregnancy and vaccines.Please see related article: https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-018-1187-3

    Biologie cellulaire et moléculaireGénétiqueBiostatistiques et épidémiologieLicence : Open Access http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/publicdomain/zero/1.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (), which permits unrestricted use, distribution, and reproduction in any medium, provid
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  • Article libreArticleEn anglais

    How Hydroxyurea Alters the Gut Microbiome: A Longitudinal Study Involving Angolan Children with Sickle Cell Anemia

    Sickle cell anemia (SCA) is an inherited hematological disorder and a serious global health problem, especially in Sub-Saharan Africa. Although hydroxyurea (HU) is the leading treatment for patients with SCA, its effects on the gut microbiome have not yet been explored. In this context, the aim of this study was to investigate this association by characterizing the gut microbiome of an Angolan SCA pediatric population before and after 6 months of HU treatment. A total of 66 stool samples were obtained and sequenced for the 16S rRNA gene (V3-V4 regions). Significant associations were observed in alpha and beta-diversity, with higher values of species richness for the children naïve for HU. We also noticed that children after HU had higher proportions of several beneficial bacteria, mostly short-chain fatty acids (SCFAs) producing species, such as Blautia luti, Roseburia inulinivorans, Eubacterium halli, Faecalibacterium, Ruminococcus, Lactobacillus rogosae, among others. In addition, before HU there was a higher abundance of Clostridium_g24, which includes C. bolteae and C. clostridioforme, both considered pathogenic. This study provides the first evidence of the HU effect on the gut microbiome and unravels several microorganisms that could be considered candidate biomarkers for disease severity and HU efficacy.

    Biologie cellulaire et moléculaireGénétiqueHématologieLicence : https://creativecommons.org/licenses/by/4.0/ Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ().
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  • Article libreArticleEn anglais

    How light is too light touch: The effect of a short training-based intervention on household poultry production in Burkina Faso☆

    Jessica Leight, Josué Awonon, Abdoulaye Pedehombga, Rasmané Ganaba, Aulo Gelli

    This paper reports on the effects of a training-based intervention seeking to increase household engagement in poultry production in Burkina Faso, analyzing data from a large-scale cluster randomized trial in which 1798 households in 60 communes were observed over a period of three years. The intervention SELEVER — entailing a short series of trainings for households as well as capacity building for local animal health and credit services — had little effect on household poultry production and no effect on profits. There is some evidence of an increase in the utilization of poultry inputs and an associated reduction in poultry mortality, primarily for larger poultry producers; however, there is no evidence of any treatment effects for the smallest producers. Highlights•A short training-based intervention seeking to increase household engagement in poultry production in Burkina Faso was not effective in increasing poultry flock size or revenue.•Larger producers did show evidence of a shift in poultry practices, and a higher level of poultry knowledge.•However, smaller and more subsistence-oriented producers were largely unresponsive.

    Santé publiqueLicence : This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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  • Article libreArticleEn anglais

    How migration shapes modern contraceptive use among urban young women: Evidence from six African countries

    BackgroundInternal migration is an important part of the transition to adulthood for many young people in sub-Saharan Africa. This study examines how migration, in relation to marriage and parenthood, impacts modern contraceptive use and health facility visits amongst young urban women.MethodsWe draw on Performance Monitoring for Action (PMA) surveys conducted in Burkina Faso, Côte d’Ivoire, Democratic Republic of Congo, Kenya, Nigeria, and Uganda (2019–2022). Our analysis is unique in being able to adjust for whether women wanted to get pregnant soon. Our sample includes women ages 15–24 years currently residing in urban areas (n = 6,225). We conducted logistic regression models clustered by village level identifier to explore the sequence of life events and the timing of migration in relation to current modern contraceptive use and recent health facility visit, a proxy for engagement with formal health services.ResultsThe timing of migration matters more than the sequence of these life events. Young urban women who experienced both migration and a birth, regardless of the order, had increased contraceptive use and recent health facility visit, compared to women who had only experienced one event or neither. Young women who migrated in the past year had 24% lower odds of using a modern method (Odds Ratio = 0.76; 95% confidence interval 0.63, 0.91), adjusting for demographic factors and adjusting for fertility preference (Wanting to get pregnant soon). Having had a birth was highly significant for health facility visit and among women who had had a birth, those who migrated in the last year had lower odds of a recent visit (OR = 0.68, 95% CI 0.41, 0.89). Results suggest an initially disruptive effect of migration.DiscussionOur results suggest young women who recently migrated to urban areas may need additional support in accessing contraception and formal health services for themselves or their children.

    Biologie cellulaire et moléculaireGénétiqueBiostatistiques et épidémiologieLicence : Creative Commons Attribution License This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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  • Article libreArticleEn anglais

    How much does community-based targeting of the ultra-poor in the health sector cost? Novel evidence from Burkina Faso

    Yvonne Beaugé, Jean-Louis Koulidiati, Valéry Ridde, Paul Jacob Robyn, Manuela De Allegri

    BackgroundTargeting efforts aimed at increasing access to care for the poorest by reducing to a minimum or completely eliminating payments at point of use are increasingly being adopted across low and middle income countries, within the framework of Universal Health Coverage policies. No evidence, however, is available on the real cost of designing and implementing these efforts. Our study aimed to fill this gap in knowledge through the systematic assessment of both the financial and economic costs associated with designing and implementing a pro-poor community-based targeting intervention across eight districts in rural Burkina Faso.MethodsWe conducted a partial retrospective economic evaluation (i.e. estimating costs, but not benefits) associated with the abovementioned targeting intervention. We adopted a health system perspective, including all costs incurred by the government and its development partners as well as costs incurred by the community when working as volunteers on behalf of government structures. To trace both financial and economic costs, we combined Activity-Based Costing with Resource Consumption Accounting. To this purpose, we consulted and extracted information from all relevant design/implementation documents and conducted additional key informant structured interviews to assess the resource consumption that was not valued in the documents.ResultsFor the entire community-based targeting intervention, we estimated a financial cost of USD 587,510 and an economic cost of USD 1,213,447. The difference was driven primarily by the value of the time contributed by the community. Communities carried the main economic burden. With a total of 102,609 ultra-poor identified, the financial cost and the economic cost per ultra-poor person were respectively USD 5,73 and USD 11,83.ConclusionThe study is first of its kind to accurately trace the financial and economic costs of a community-based targeting intervention aiming to identify the ultra-poor. The fina

    Santé publiqueLicence : Open Access http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original aut
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  • Article libreArticleEn anglais

    How Properties of Kenaf Fibers from Burkina Faso Contribute to the Reinforcement of Earth Blocks

    Physicochemical characteristics of Hibiscus cannabinus (kenaf) fibers from Burkina Faso were studied using X-ray diffraction (XRD), infrared spectroscopy, thermal gravimetric analysis (TGA), chemical analysis and video microscopy. Kenaf fibers (3 cm long) were used to reinforce earth blocks, and the mechanical properties of reinforced blocks, with fiber contents ranging from 0.2 to 0.8 wt%, were investigated. The fibers were mainly composed of cellulose type I (70.4 wt%), hemicelluloses (18.9 wt%) and lignin (3 wt%) and were characterized by high tensile strength (1 ± 0.25 GPa) and Young’s modulus (136 ± 25 GPa), linked to their high cellulose content. The incorporation of short fibers of kenaf reduced the propagation of cracks in the blocks, through the good adherence of fibers to the clay matrix, and therefore improved their mechanical properties. Fiber incorporation was particularly beneficial for the bending strength of earth blocks because it reinforces these blocks after the failure of soil matrix observed for unreinforced blocks. Blocks reinforced with such fibers had a ductile tensile behavior that made them better building materials for masonry structures than unreinforced blocks.

    Santé publiqueLicence : http://creativecommons.org/licenses/by/4.0/ licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license ().
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  • Article libreArticleEn anglais

    How to develop a theory-driven evaluation design? Lessons learned from an adolescent sexual and reproductive health programme in West Africa

    Sara B Van Belle, Bruno Marchal, Dominique Dubourg, Guy Kegels

    BackgroundThis paper presents the development of a study design built on the principles of theory-driven evaluation. The theory-driven evaluation approach was used to evaluate an adolescent sexual and reproductive health intervention in Mali, Burkina Faso and Cameroon to improve continuity of care through the creation of networks of social and health care providers.Methods/designBased on our experience and the existing literature, we developed a six-step framework for the design of theory-driven evaluations, which we applied in the ex-post evaluation of the networking component of the intervention. The protocol was drafted with the input of the intervention designer. The programme theory, the central element of theory-driven evaluation, was constructed on the basis of semi-structured interviews with designers, implementers and beneficiaries and an analysis of the intervention's logical framework.DiscussionThe six-step framework proved useful as it allowed for a systematic development of the protocol. We describe the challenges at each step. We found that there is little practical guidance in the existing literature, and also a mix up of terminology of theory-driven evaluation approaches. There is a need for empirical methodological development in order to refine the tools to be used in theory driven evaluation. We conclude that ex-post evaluations of programmes can be based on such an approach if the required information on context and mechanisms is collected during the programme.

    Santé publiqueLicence : http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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  • Article libreArticleEn anglais

    How to Estimate Optimal Malaria Readiness Indicators at Health-District Level: Findings from the Burkina Faso Service Availability and Readiness Assessment (SARA) Data

    Toussaint Rouamba, Sekou Samadoulougou, Cheick Saïd Compaoré, Halidou Tinto, Jean Gaudart, Fati Kirakoya-Samadoulougou

    One of the major contributors of malaria-related deaths in Sub-Saharan African countries is the limited accessibility to quality care. In these countries, malaria control activities are implemented at the health-district level (operational entity of the national health system), while malaria readiness indicators are regionally representative. This study provides an approach for estimating health district-level malaria readiness indicators from survey data designed to provide regionally representative estimates. A binomial-hierarchical Bayesian spatial prediction method was applied to Burkina Faso Service Availability and Readiness Assessment (SARA) survey data to provide estimates of essential equipment availability and readiness for malaria care. Predicted values of each indicator were adjusted by the type of health facility, location, and population density. Then, a health district composite readiness profile was built via hierarchical ascendant classification. All surveyed health-facilities were mandated by the Ministry of Health to manage malaria cases. The spatial distribution of essential equipment and malaria readiness was heterogeneous. Around 62.9% of health districts had a high level of readiness to provide malaria care and prevention during pregnancy. Low-performance scores for managing malaria cases were found in big cities. Health districts with low coverage for both first-line antimalarial drugs and rapid diagnostic tests were Baskuy, Bogodogo, Boulmiougou, Nongr-Massoum, Sig-Nonghin, Dafra, and Do. We provide health district estimates and reveal gaps in basic equipment and malaria management resources in some districts that need to be filled. By providing local-scale estimates, this approach could be replicated for other types of indicators to inform decision makers and health program managers and to identify priority areas.

    Biostatistiques et épidémiologieParasitologie et mycologiePharmacologieLicence : http://creativecommons.org/licenses/by/4.0/ Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ().
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    How West African countries prioritize health

    Yusuff Adebayo Adebisi, Aishat Alaran, Abubakar Badmos, Adeola Oluwaseyi Bamisaiye, Nzeribe Emmanuella, Alison Ubong Etukakpan, Iyiola Olatunji Oladunjoye, Oladipo Oluwaseyifunmi, Shingin Kovona Musa, Temiwunmi Akinmuleya, Omotayo Carolyn Olaoye, Obafemi Arinola Olarewaju, Don Eliseo Lucero-Prisno

    BackgroundThe goal of Universal Health Coverage (UHC) is to ensure that everyone is able to obtain the health services they need without suffering financial hardship. UHC remains a mirage if government health expenditure is not improved. Health priority refers to general government health expenditure as a percentage of general government expenditure. It indicates the priority of the government to spend on healthcare from its domestic public resources. Our study aimed to assess health priorities in the Economic Community of West African States (ECOWAS) using the health priority index from the WHO’s Global Health Expenditure Database.MethodWe extracted and analysed data on health priority in the WHO’s Global Health Expenditure Database across the 15 members of the ECOWAS (Benin, Burkina Faso, Cabo Verde, Cote d'Ivoire, The Gambia, Ghana, Guinea, Guinea-Bissau, Liberia, Mali, Niger, Nigeria, Senegal, Sierra Leone, and Togo) from 2010 to 2018 to assess how these countries prioritize health. The data are presented using descriptive statistics.ResultsOur findings revealed that no West African country beats the cutoff of a minimum of 15% health priority index. Ghana (8.43%), Carbo Verde (8.29%), and Burkina Faso (7.60%) were the top three countries with the highest average health priority index, while Guinea (3.05%), Liberia (3.46%), and Guinea-Bissau (3.56%) had the lowest average health priority in the West African region within the period of our analysis (2010 to 2018).ConclusionOur study reiterates the need for West African governments and other relevant stakeholders to prioritize health in their political agenda towards achieving UHC.

    Santé publiqueLicence : Open Access http://creativecommons.org/licenses/by/4.0/ This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original autho
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    HRP2 and pLDH-Based Rapid Diagnostic Tests, Expert Microscopy, and PCR for Detection of Malaria Infection during Pregnancy and at Delivery in Areas of Varied Transmission: A Prospective Cohort Study in Burkina Faso and Uganda

    BackgroundIntermittent screening and treatment (IST) of malaria during pregnancy has been proposed as an alternative to intermittent preventive treatment in pregnancy (IPTp), where IPTp is failing due to drug resistance. However, the antenatal parasitaemias are frequently very low, and the most appropriate screening test for IST has not been defined.Methodology/Principal FindingsWe conducted a multi-center prospective study of 990 HIV-uninfected women attending ANC in two different malaria transmission settings at Tororo District Hospital, eastern Uganda and Colsama Health Center in western Burkina Faso. Women were enrolled in the study in the second or third trimester of pregnancy and followed to delivery, generating 2,597 blood samples for analysis. Screening tests included rapid diagnostic tests (RDTs) targeting histidine-rich protein 2 (HRP2) and parasite lactate dehydrogenase (pLDH) and microscopy, compared to nPCR as a reference standard. At enrolment, the proportion of pregnant women who were positive for P. falciparum by HRP2/pan pLDH RDT, Pf pLDH/pan pLDH RDT, microscopy and PCR was 38%, 29%, 36% and 44% in Uganda and 21%, 16%, 15% and 35% in Burkina Faso, respectively. All test positivity rates declined during follow-up. In comparison to PCR, the sensitivity of the HRP2/pan pLDH RDT, Pf pLDH/pan pLDH RDT and microscopy was 75.7%, 60.1% and 69.7% in Uganda, 55.8%, 42.6% and 55.8% in Burkina Faso respectively for all antenatal visits. Specificity was greater than 96% for all three tests. Comparison of accuracy using generalized estimating equation revealed that the HRP2- detecting RDT was the most accurate test in both settings.Conclusions/SignificanceThe study suggests that HRP2-based RDTs are the most appropriate point-of-care test currently available for use during pregnancy especially for symptomatic women, but will still miss some PCR-positive women. The clinical significance of these very low density infections needs to be better defined.

    Biologie cellulaire et moléculaireGénétiqueBiostatistiques et épidémiologieLicence : Creative Commons Attribution License This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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    Human capital and lifetime income gains of scaling-up small-quantity lipid nutrient supplements among children under 2 years: A modelling analysis

    Undernutrition in early childhood is associated with adverse health and developmental outcomes later in life and remains a persistent global public health problem. Providing small-quantity lipid nutrient supplements (SQ-LNS) to children aged 6-24 months improves child growth and neurodevelopmental outcomes, but the potential long-term benefits to human capital have not been previously estimated. We estimated the potential returns to schooling and lifetime income attributable to increasing coverage of SQ-LNS for children <2 years of age from 0% to 50% or 90% per five-year birth cohort in five countries (Bangladesh, Burkina Faso, Ethiopia, Pakistan, and Uganda) with a high burden of undernutrition. Random-effects meta-analyses were used to estimate the effect of SQ-LNS on child development using evidence from randomized controlled trials, and to estimate the returns to lifetime income as a function of change in development based on a de novo meta-analysis of observational economic studies. Gains in school years attributable to scaling-up SQ-LNS to 90% coverage ranged from 0.14 million school years (95% uncertainty interval [UI]: 0.064, 0.25) in Burkina Faso to 1.18 million school years (95%UI: 0.54, 2.11) in Pakistan per five-year birth cohort. With an effect size of 18% return in income per one standard deviation increase in development, the estimated gains in lifetime income ranged from $US 0.41 billion (95% UI: 0.20, 0.68) in Burkina Faso to $US 6.91 billion (95% UI: 3.32, 11.4) in Pakistan per five-year birth cohort. Returns in income per child were above the estimated per child cost of providing SQ-LNS. These findings demonstrate that scaling-up SQ-LNS among children aged 6-24 months may lead to substantial human capital gains in countries with a high-burden of child undernutrition. Longitudinal studies on the long-term effects of SQ-LNS are needed to refine model parameters and to better characterize the impacts on broader health and human capital outcomes.

    Biostatistiques et épidémiologiePédiatrieSanté publiqueLicence : Creative Commons Attribution License This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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    Human genetic variant E756del in the ion channel PIEZO1 not associated with protection from severe malaria in a large Ghanaian study

    Thorsten Thye, Jennifer A. Evans, Gerd Ruge, Wibke Loag, Daniel Ansong, Tsiri Agbenyega, Rolf D. Horstmann, Jürgen May, Kathrin Schuldt

    Recently, a common genetic variant E756del in the human gene PIEZO1 was associated with protection from severe malaria. Here, we performed a genetic association study of this gain-of-function variant in a large case-control study including 4149 children from the Ashanti Region in Ghana, West Africa. The statistical analysis did not indicate an association with protection from severe malaria and, thus, providing evidence against a strong protective effect of the PIEZO1 E756del variant on severe malaria susceptibility.

    Biologie cellulaire et moléculaireGénétiqueParasitologie et mycologieLicence : Open Access http://creativecommons.org/licenses/by/4.0/ This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original autho
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    Human IgG responses to Anopheles gambiae immunogenic salivary proteins in urban and rural populations of Burkina Faso: biomarkers of exposure to malaria vector bites

    Michaël Kaboré, Yéri Esther Hien, Dado Jean Noël Koussé, Fatimata Thiombiano, Mireille Ouédraogo, Abdoul Rahamani Nikiema, Enock Ibrango, Nicolas Ouédraogo, Mariama K. Cherif, Sylvain Ilboudo, Toussaint Rouamba, Guillaume Sylvestre Sanou

    BackgroundMalaria control would be greatly facilitated by the development of new tools for rapidly assessing malaria transmission intensity. In malaria-endemic areas such as Burkina Faso, human populations are frequently exposed to immunomodulatory salivary components injected during mosquito blood feeding. Numerous studies have examined parasite immunity; however, there are few data available on vector immunity as a means of assessing malaria transmission in sub-Saharan Africa. The present study aims to compare IgG-specific response to salivary gland extracts (SGE) of Anopheles gambiae (An. gambiae) in populations living in urban and rural areas in Burkina Faso.MethodsA cross-sectional descriptive study was carried out in two sites, Ouagadougou city and Sapouy village, where blood samples (n = 676) from children (0–15 years) and adults were collected. After An. gambiae salivary protein isolation, the antibody (IgG) response to those SGE was evaluated by enzyme-linked immunosorbent assay (ELISA), representing a proxy of Anopheles exposure. The difference in antibody concentrations between groups was tested using parametric tests (Student’s t-test and analysis of variance [ANOVA]) and the nonparametric Mann–Whitney U (Wilcoxon rank-sum) test. All differences were considered significant at P < 0.05.ResultsThe study population consisted of 63.0% males and 37.0% females (average age = 31.2 ± 17.8 years). IgG antibodies against An. gambiae salivary protein were detected in all study participants. Urban participants demonstrated a greater mean IgG level to An. gambiae bites than rural (P < 0.0001). The mean IgG level was higher in secondary school children compared with primary school children (P < 0.0001). Organic cotton farmers held higher IgG to An. gambiae bites than conventional cotton farmers (P = 0.0027).ConclusionsThe evaluation of IgG specific to mosquito salivary gland extracts as immunological biomarkers in populations in Burkina Faso allowed us to show that th

    Parasitologie et mycologieImmunologieMaladies infectieuses et tropicalesLicence : Open Access http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/publicdomain/zero/1.0/ This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as
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    Human immunodeficiency virus (HIV) among men who have sex with men: results of the first integrated biological and behavioral survey in Burkina Faso, West Africa

    Henri Gautier Ouedraogo, Odette Ky-Zerbo, Ashley Grosso, Sara Goodman, Benoît Cesaire Samadoulougou, Grissoum Tarnagda, Adama Baguiya, Simon Tiendrebeogo, Marcel Lougue, Nongoba Sawadogo, Yves Traore, Nicolas Barro, Stefan Baral, Seni Kouanda

    BackgroundMany men who have sex with men (MSM) are at significant risk for HIV infection. The objective of this study was to determine the prevalence and correlates of HIV infection among MSM in Burkina Faso.MethodsA cross-sectional biological and behavioral survey was conducted from January to August 2013 among MSM in Ouagadougou and Bobo-Dioulasso. MSM 18 years old and above were recruited using respondent driven sampling (RDS). A survey was administered to study participants followed by HIV testing. Population prevalence estimates and 95% confidence intervals (CI) adjusted for the RDS design were produced using the RDS Analysis Tool version 6.0.1 (RDS, Inc., Ithaca, NY).ResultsA total of 662 MSM were enrolled in Ouagadougou (n = 333) and Bobo-Dioulasso (n = 329). The majority were unmarried, with an average age of 22.1 ± 4.4 years old in Ouagadougou and 23.1 ± 4.7 years old in Bobo-Dioulasso. RDS-adjusted HIV prevalence was 1.7% (95% CI: 0.9–3.1) in Ouagadougou and 2.7% (95% CI: 1.6–4.6) in Bobo-Dioulasso. HIV prevalence among MSM under 25 years old was 1.3% (95% CI: 0.6–2.8) and 0.9% (95% CI: 0.4–2.5) respectively in Ouagadougou and Bobo-Dioulasso, compared to 5.4% (95% CI: 2.2–12.5) and 6.6% (95% CI: 3.4–12.3) among those 25 years old or older in these cities (p = 0.010 and p < 0.001).ConclusionsResults from this first biological and behavioral survey among MSM in Burkina Faso suggest a need for programs to raise awareness among MSM and promote safer sex, particularly for young MSM to prevent HIV transmission. These programs would need support from donors for innovative actions such as promoting and providing pre-exposure prophylaxis, condoms and water-based lubricants, HIV counseling, testing, early treatment initiation and effective involvement of the MSM communities.

    Biostatistiques et épidémiologieImmunologieMaladies infectieuses et tropicalesLicence : Open Access http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/publicdomain/zero/1.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (), which permits unrestricted use, distribution, and reproduction in any medium, provid
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    Human papillomavirus genotype distribution and cervical squamous intraepithelial lesions among high-risk women with and without HIV-1 infection in Burkina Faso

    M-N Didelot-Rousseau, N Nagot, V Costes-Martineau, X Vallès, A Ouedraogo, I Konate, H A Weiss, P Van de Perre, P Mayaud, M Segondy

    Human papillomavirus (HPV) infection and cervical squamous intraepithelial lesions (SILs) were studied in 379 high-risk women. Human papillomavirus DNA was detected in 238 of 360 (66.1%) of the beta-globin-positive cervical samples, and 467 HPV isolates belonging to 35 types were identified. Multiple (2–7 types) HPV infections were observed in 52.9% of HPV-infected women. The most prevalent HPV types were HPV-52 (14.7%), HPV-35 (9.4%), HPV-58 (9.4%), HPV-51 (8.6%), HPV-16 (7.8%), HPV-31 (7.5%), HPV-53 (6.7%), and HPV-18 (6.4%). Human immunodeficiency virus type 1 (HIV-1) seroprevalence was 36.0%. Human papillomavirus prevalence was significantly higher in HIV-1-infected women (87 vs 54%, prevalence ratio (PR)=1.61, 95% confidence interval (CI): 1.4–1.8). High-risk HPV types (71 vs 40%, PR=1.79, 95% CI: 1.5–2.2), in particular HPV-16+18 (22 vs 9%, PR=2.35, 95% CI: 1.4–4.0), and multiple HPV infections (56 vs 23%, PR=2.45, 95% CI: 1.8–3.3) were more prevalent in HIV-1-infected women. High-grade SIL (HSIL) was identified in 3.8% of the women. Human immunodeficiency virus type 1 infection was strongly associated with presence of HSIL (adjusted odds ratio=17.0; 95% CI 2.2–134.1, P=0.007) after controlling for high-risk HPV infection and other risk factors for HSIL. Nine of 14 (63%) HSIL cases were associated with HPV-16 or HPV-18 infection, and might have been prevented by an effective HPV-16/18 vaccine.

    Biostatistiques et épidémiologieImmunologieMaladies infectieuses et tropicalesLicence : https://creativecommons.org/licenses/by/4.0/ This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and th
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