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La bibliothèque des étudiants en santé

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  • Article libreArticleEn anglais

    Novel insights on the geomagnetic field in West Africa from a new intensity reference curve (0-2000 AD)

    Lisa Kapper, Vincent Serneels, Sanja Panovska, Rafael García Ruíz, Gabrielle Hellio, Lennart de Groot, Avto Goguitchaichvili, Juan Morales, Rubén Cejudo Ruíz

    The geomagnetic field variations on the continent of Africa are still largely undeciphered for the past two millennia. In spite of archaeological artefacts being reliable recorders of the ancient geomagnetic field strength, only few data have been reported for this continent so far. Here we use the Thellier-Coe and calibrated pseudo-Thellier methods to recover archaeointensity data from Burkina Faso and Ivory Coast (West Africa) from well-dated archaeological artefacts. By combining our 18 new data with previously published data from West Africa, we construct a reference curve for West Africa for the past 2000 years. To obtain a reliable curve of the archaeointensity variation, we evaluate a penalized smoothing spline fit and a stochastic modelling method, both combined with a bootstrap approach. Both intensity curves agree well, supporting the confidence in our proposed intensity variation during this time span, and small differences arise from the different methodologies of treating data and uncertainties. Two prominent peaks at around 740 AD and 1050 AD appear to be common in ours and several reference curves from other locations, indicating a general westward movement from China to Hawaii of a rather stable feature of the geomagnetic field. However, independent smaller peaks that do not correlate in different locations may hint to localized expressions of the geomagnetic field as a result of temporarily varying non-dipole sources.

    Santé publiqueLicence : Open Access http://creativecommons.org/licenses/by/4.0/ This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original autho
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  • Article libreArticleEn anglais

    Novel Wolbachia strains in Anopheles malaria vectors from Sub-Saharan Africa

    Claire L. Jeffries, Gena G. Lawrence, George Golovko, Mojca Kristan, James Orsborne, Kirstin Spence, Eliot Hurn, Janvier Bandibabone, Luciano M. Tantely, Fara N. Raharimalala, Kalil Keita, Denka Camara, Yaya Barry, Francis Wat’senga, Emile Z. Manzambi, Yaw A. Afrane, Abdul R. Mohammed, Tarekegn A. Abeku, Shivanand Hedge, Kamil Khanipov, Maria Pimenova, Yuriy Fofanov, Sebastien Boyer, Seth R. Irish, Grant L. Hughes, Thomas Walker

    Background: Wolbachia, a common insect endosymbiotic bacterium that can influence pathogen transmission and manipulate host reproduction, has historically been considered absent from the Anopheles (An.) genera, but has recently been found in An. gambiae s.l. populations in West Africa. As there are numerous Anopheles species that have the capacity to transmit malaria, we analysed a range of species across five malaria endemic countries to determine Wolbachia prevalence rates, characterise novel Wolbachia strains and determine any correlation between the presence of Plasmodium, Wolbachia and the competing bacterium Asaia. Methods: Anopheles adult mosquitoes were collected from five malaria-endemic countries: Guinea, Democratic Republic of the Congo (DRC), Ghana, Uganda and Madagascar, between 2013 and 2017. Molecular analysis was undertaken using quantitative PCR, Sanger sequencing, Wolbachia multilocus sequence typing (MLST) and high-throughput amplicon sequencing of the bacterial 16S rRNA gene. Results: Novel Wolbachia strains were discovered in five species: An. coluzzii, An. gambiae s.s., An. arabiensis, An. moucheti and An. species A, increasing the number of Anopheles species known to be naturally infected. Variable prevalence rates in different locations were observed and novel strains were phylogenetically diverse, clustering with Wolbachia supergroup B strains. We also provide evidence for resident strain variants within An. species A. Wolbachia is the dominant member of the microbiome in An. moucheti and An. species A but present at lower densities in An. coluzzii. Interestingly, no evidence of Wolbachia/Asaia co-infections was seen and Asaia infection densities were shown to be variable and location dependent. Conclusions: The important discovery of novel Wolbachia strains in Anopheles provides greater insight into the prevalence of resident Wolbachia strains in diverse malaria vectors. Novel Wolbachia strains (particularly high-density strains) are ideal

    Biologie cellulaire et moléculaireGénétiqueBiostatistiques et épidémiologieLicence : This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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  • Article libreArticleEn anglais

    Nursing and midwife staffing needs in maternity wards in Burkina Faso referral hospitals

    Antarou Ly, Séni Kouanda, Valéry Ridde

    BackgroundIn 2006, Burkina Faso set up a policy to subsidize the cost of obstetric and neonatal emergency care. This policy has undoubtedly increased attendance at all levels of the health pyramid. The aim of this study was to measure the capacity of referral hospitals’ maternity services to cope with the demand for health services after the implementation of this policy.MethodsThis study was conducted in three referral health centres (CMAs, CHRs, and CHUs). The CHU Yalgado Ouédraogo (tertiary level) and the CMA in Sector 30 (primary level) were selected as health facilities in the capital, along with the Kaya CHR (secondary level). At each health facility, the study included official maternity ward staff only. We combined the two occupational categories (nurses and midwives) because they perform the same activities in these health facilities. We used the WISN method recommended by WHO to assess the availability of nurses and midwives.ResultsNurses and midwives represented 38% of staff at the University Hospital, 65% in the CHR and 80% in the CMA. The number of nurses and midwives needed for carrying out the activities in the maternity ward in the University Hospital and the CMA is greater than the current workforce, with WISN ratio of 0.68 and 0.79 respectively. In the CHR, the current workforce is greater than the number required (WISN ratio = 2).This medical centre is known for performing a high number curative and preventive activities compared to the Kaya CHR. Like the CHU, the delivery room is a very busy unit. This activity requires more time and more staff compared to other activities.ConclusionThis study showed a shortage of nurses and midwives in two health facilities in Ouagadougou, which confirms that there is considerable demand. At the Kaya CHR, there is currently enough staff to handle the workload in the maternity ward, which may indicate a need to expand the analysis to other health facilities to determine whether a redistribution of health human re

    PédiatrieGynécologie-obstétriqueSanté publiqueLicence : http://creativecommons.org/licenses/by/4.0 http://creativecommons.org/publicdomain/zero/1.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (), which permits unrestricted use, distribution, and reproduction in any medium, provided the original
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  • Article libreArticleEn anglais

    Nutrient Profiles of Commercially Produced Complementary Foods Available in Burkina Faso, Cameroon, Ghana, Nigeria and Senegal

    The nutritional quality of commercially produced complementary food (CPCF) varies widely, with CPCF in high-income settings often containing excessive levels of sugar and sodium. Little is known about the nutritional quality of CPCF available in the West Africa region, despite their potential to improve the nutrition of infants and young children (IYC). This study evaluated the nutritional quality of CPCF available in five West African countries using the WHO Europe nutrient profiling model (NPM) and assessed their suitability for IYC based on label information. The proportion that would necessitate a “high sugar” warning was also determined, and the micronutrient (iron, calcium, and zinc) content was assessed against IYC-recommended nutrient intakes. Of the 666 products assessed, only 15.9% were classified as nutritionally suitable for promotion for IYC. The presence of added sugar and excessive sodium levels were the most common reasons for a product to fail the nutrient profiling assessment. Dry/instant cereals contributed the highest percentage of recommended nutrient intake (RNI) per serving. This highlights the need for policies to improve the nutritional quality of CPCF in West Africa, including labeling standards and the use of front-of-pack warning signs to promote product reformulation and clearly communicate nutritional quality to caregivers.

    PédiatrieSanté publiqueLicence : https://creativecommons.org/licenses/by/4.0/ Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ().
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  • Article libreArticleEn anglais

    NUTRItion and CLIMate (NUTRICLIM): investigating the relationship between climate variables and childhood malnutrition through agriculture, an exploratory study in Burkina Faso

    Raissa Sorgho, Jonas Franke, Seraphin Simboro, Revati Phalkey, Rainer Saeurborn

    Malnutrition remains a leading cause of death in children in low- and middle-income countries; this will be aggravated by climate change. Annually, 6.9 million deaths of children under 5 were attributable directly or indirectly to malnutrition. Although these figures have recently decreased, evidence shows that a world with a medium climate (local warming up to 3–4 °C) will create an additional 25.2 million malnourished children. This proof of concept study explores the relationships between childhood malnutrition (more specifically stunting), regional agricultural yields, and climate variables through the use of remote sensing (RS) satellite imaging along with algorithms to predict the effect of climate variability on agricultural yields and on malnutrition of children under 5. The success of this proof of purpose study, NUTRItion and CLIMate (NUTRICLIM), should encourage researchers to apply both concept and tools to study of the link between weather variability, crop yield, and malnutrition on a larger scale. It would also allow for linking such micro-level data to climate models and address the challenge of projecting the additional impact of childhood malnutrition from climate change to various policy relevant time horizons.

    PédiatrieSanté publiqueLicence : Open Access http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/publicdomain/zero/1.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (), which permits unrestricted use, distribution, and reproduction in any medium, provid
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  • Article libreArticleEn anglais

    Nutrition Intervention Coverage and Inequities Along the Continuum of Care: Results From the Eighth Demographic and Health Survey in Six Sub‐Saharan African Countries

    Erica Phillips, Stephanie Zobrist, Erin M. Milner, Jacqueline K. Kung'u, Rebecca A. Heidkamp, Rukundo K. Benedict

    ABSTRACTMany countries rely on national household surveys to monitor coverage of nutrition interventions. Following a multi‐year consultative effort, 14 new and revised nutrition coverage indicators were included in the Round 8 Demographic and Health Survey (DHS‐8) core questionnaire. These indicators were better aligned with international recommendations and generate actionable data for policy and programmatic decision making at national, subnational, and global levels. This analysis highlights their potential applications. We included six sub‐Saharan African countries who collected and released DHS‐8 datasets between January 2021 and June 2024 (Burkina Faso, Côte d'Ivoire, Ghana, Kenya, Mozambique, and Tanzania). We present weighted averages for all nutrition coverage indicators from pregnancy through young childhood by country and estimate inequities in coverage. Coverage of nutrition interventions provided during pregnancy, birth, and postnatal care was higher than during infancy and young childhood, with wide variation between and within countries. For the new indicators on prenatal counseling about breastfeeding and maternal diet, Ghana had the highest coverage (88% and 92%, respectively) and Mozambique the lowest (48% and 51%). Postnatal counseling about infant and young child feeding practices was universally lower, ranging from 12% in Mozambique to 50% in Ghana. Subnational region, wealth quartile, and maternal education were consistent drivers of inequity. The greatest differences in coverage were by subnational region, as high as 71 percentage points for coverage of height and weight measurement of young children in Kenya. The expanded DHS‐8 nutrition indicators fill critical information gaps about coverage and inequalities in care. Summary The Demographic and Health Survey‐8 core questionnaire was expanded to include a broader range of nutrition intervention coverage indicators.Coverage indicators are actionable and pragmatic and facilitate policy and pr

    Biostatistiques et épidémiologiePédiatrieGynécologie-obstétriqueLicence : http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of theLicense, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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  • Article libreArticleEn anglais

    Nutrition rehabilitation of undernourished children utilizing Spiruline and Misola

    Jacques Simpore, Fatoumata Kabore, Frederic Zongo, Deleli Dansou, Augustin Bere, Salvatore Pignatelli, Daniela M Biondi, Giuseppe Ruberto, Salvatore Musumeci

    BackgroundMalnutrition constitutes a public health problem throughout the world and particularly in developing countries.AimsThe objective of the study is to assess the impact of an elementary integrator composed of Spiruline (Spirulina platensis) and Misola (millet, soja, peanut) produced at the Centre Medical St Camille (CMSC) of Ouagadougou, Burkina Faso, on the nutritional status of undernourished children.Materials and methods550 undernourished children of less than 5 years old were enrolled in this study, 455 showed severe marasma, 57 marasma of medium severity and 38 kwashiorkor plus marasma. We divided the children randomly into four groups: 170 were given Misola (731 ± 7 kcal/day), 170 were given Spiruline plus traditional meals (748 ± 6 kcal/day), 170 were given Spiruline plus Misola (767 ± 5 kcal/day). Forty children received only traditional meals (722 ± 8 kcal/day) and functioned as the control group. The duration of this study was eight weeks.Results and DiscussionAnthropometrics and haematological parameters allowed us to appreciate both the nutritional and biological evolution of these children. The rehabilitation with Spiruline plus Misola (this association gave an energy intake of 767 ± 5 kcal/day with a protein assumption of 33.3 ± 1.2 g a day), both greater than Misola or Spiruline alone, seems to correct weight loss more quickly.ConclusionOur results indicate that Misola, Spiruline plus traditional meals or Spiruline plus Misola are all a good food supplement for undernourished children, but the rehabilitation by Spiruline plus Misola seems synergically favour the nutrition rehabilitation better than the simple addition of protein and energy intake.

    PédiatrieSanté publiqueLicence : This is an Open Access article distributed under the terms of the Creative Commons Attribution License (), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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  • Article libreArticleEn anglais

    Nutrition surveillance using a small open cohort: experience from Burkina Faso

    Mathias Altmann, Christophe Fermanian, Boshen Jiao, Chiara Altare, Martin Loada, Mark Myatt

    BackgroundNutritional surveillance remains generally weak and early warning systems are needed in areas with high burden of acute under-nutrition. In order to enhance insight into nutritional surveillance, a community-based sentinel sites approach, known as the Listening Posts (LP) Project, was piloted in Burkina Faso by Action Contre la Faim (ACF). This paper presents ACF’s experience with the LP approach and investigates potential selection and observational biases.MethodsSix primary sampling units (PSUs) were selected in each livelihood zone using the centric systematic area sampling methodology. In each PSU, 22 children aged between 6 and 24 months were selected by proximity sampling. The prevalence of GAM for each month from January 2011 to December 2013 was estimated using a Bayesian normal–normal conjugate analysis followed by PROBIT estimation. To validate the LP approach in detecting changes over time, the time trends of MUAC from LP and from five cross-sectional surveys were modelled using polynomial regression and compared by using a Wald test. The differences between prevalence estimates from the two data sources were used to assess selection and observational biases.ResultsThe 95 % credible interval around GAM prevalence estimates using LP approach ranged between +6.5 %/−6.0 % on a prevalence of 36.1 % and +3.5 %/−2.9 % on a prevalence of 10.8 %. LP and cross-sectional surveys time trend models were well correlated (p = 0.6337). Although LP showed a slight but significant trend for GAM to decrease over time at a rate of −0.26 %/visit, the prevalence estimates from the two data sources showed good agreement over a 3-year period.ConclusionsThe LP methodology has proved to be valid in following trends of GAM prevalence for a period of 3 years without selection bias. However, a slight observational bias was observed, requiring a periodical reselection of the sentinel sites. This kind of surveillance project is suited to use in areas with high burden of acut

    Biostatistiques et épidémiologiePédiatrieSanté publiqueLicence : Open Access http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/publicdomain/zero/1.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (), which permits unrestricted use, distribution, and reproduction in any medium, provid
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  • Article libreArticleEn anglais

    Nutrition‐sensitive agriculture programme impacts on time use and associations with nutrition outcomes

    Mara van den Bold, Lilia Bliznashka, Gayathri Ramani, Deanna Olney, Agnes Quisumbing, Abdoulaye Pedehombga, Marcellin Ouedraogo

    AbstractSuccess of nutrition‐sensitive agriculture programmes targeted to women may be influenced by increased demands on women's and other household members' time and by time‐related trade‐offs to accommodate programme participation. However, evidence of how such programmes impact time use and whether changes in time‐related demands negatively influence maternal or child health and nutrition outcomes is limited. This paper examines the impact of Helen Keller International's Enhanced Homestead Food Production programme in Burkina Faso (2010–2012) on women's and men's time use and associations between changes in women's time use and maternal and child health and nutrition outcomes. We used quantitative data from a cluster‐randomized controlled trial (baseline 2010, endline 2012) and qualitative data from two rounds of process evaluation (2011, 2012). Two‐stage analyses were used to first assess programme impacts on women's and men's time use using difference‐in‐difference impact estimates and second to evaluate whether programme impacts on women's time use were associated with changes in women's and children's health and nutrition outcomes. Programme impacts were considered significant if corrected P < 0.01, and associations were considered significant if p < 0.05 and p < 0.01. Qualitative data were analysed through manual coding and by calculating the means and standard deviations for the time spent by women and men on activities in intervention and control groups. Findings show that the programme significantly increased the amount of time women spent on agriculture in the intervention compared to the control group, but this was not associated with changes in maternal or child health or nutrition outcomes. Process evaluation data supported these findings.

    PédiatrieGynécologie-obstétriqueSanté publiqueLicence : http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of theLicense, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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  • Article libreArticleEn anglais

    Nutritional and Functional Properties of Defatted Flour, Protein Concentrates, and Isolates of Brachytrupes membranaceus (Orthoptera: Gryllidae) (Drury: 1773) and Macrotermes subhyalinus (Isoptera: Blattodea) (Rambur: 1842) from Burkina Faso

    Simple SummaryEdible insects are a source of nutrients for local populations. The present study evaluated proximal composition, fatty acid, and mineral profiles of Brachytrupes membranaceus and Macrotermes subhyalinus from Burkina Faso. The digestibility and functional properties of their defatted flours, protein concentrates, and isolates were also determined. Brachytrupes membranaceus protein concentrates and isolates showed the best nutritional values. They were more digestible and endowed with functional properties. The results revealed that defatted flours, concentrates, and isolates of proteins of Brachytrupes membranaceus and Macrotermes subhyalinus were alternative sources of minerals, proteins, essential amino acids, and essential fatty acids. They could, therefore, be used to combat protein, iron, and zinc deficiencies and for the bio-fortification of foods.AbstractBrachytrupes membranaceus and Macrotermes subhyalinus are edible insects in Burkina Faso. Our research aimed to evaluate the nutritional composition and functional properties of the defatted flours, protein concentrates, and isolates of Brachytrupes membranaceus and Macrotermes subhyalinus. Proximate and mineral composition were determined according to AOAC methods. The amino acid and fatty acid composition were determined by high-performance liquid chromatography (HPLC) and gas chromatography, respectively. The protein concentrates and isolates were obtained by solubilization, precipitation, and lyophilization. Macrotermes subhyalinus showed the highest protein (45.75 g/100 g), iron (11.76 mg/100 g), and zinc (13.18 mg/100 g) contents. The highest isoleucine and lysine contents, the best fat absorption (10.87 g/g), and foaming capacities (49.60%) were obtained with the isolate of Brachytrupes membranaceus. Consumption of Macrotermes subhyalinus could be used to fight or correct iron and zinc deficiencies. Macrotermes subhyalinus was a source of macronutrients and micronutrients, while the prote

    Santé publiqueLicence : https://creativecommons.org/licenses/by/4.0/ Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ().
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  • Article libreArticleEn anglais

    Nutritional and Phytochemical Potential of Two Local Food Plants in Burkina Faso: Crateva adansonii and Capparis corymbosa

    Edwige Noëlle Roamba, Frédéric Anderson Konkobo, Poussian Raymond Barry, Adama Pamba Séré, Abdoudramane Sanou, Roger Dakuyo, Kabakdé Kaboré, Kiessoun Konaté, Mamoudou Hama Dicko

    ABSTRACTThis study focused on the biochemical and nutritional characterization of two edible plant species in Burkina Faso: Capparis corymbosa and Crateva adansonii. The objective was to evaluate their proximate composition, their content of primary and secondary metabolites, minerals, and amino acids, as well as their antioxidant potential, with a view to enhancing their nutritional value. The leaves of Crateva adansonii were found to be rich in protein (26.09 g/100 g dry matter [DM]), lipids (7.09 g/100 g DM), minerals, and energy value (297.45 kcal/100 g). The fruits of Capparis corymbosa stood out for their high carbohydrate content (33.04 g/100 g DM) and vitamin A content (0.87 mg/100 g DM). The amino acid profile revealed the presence of 18 to 19 amino acids, including 8 to 9 essential amino acids, highlighting their protein value. For bioactive compounds, the butanolic fractions of the leaves of both species had the highest concentrations of total polyphenols and flavonoids. The evaluation of antioxidant activity using the DPPH, ABTS, and FRAP methods showed a high capacity for free radical scavenging, particularly for macerated extracts (DPPH: 20.58 ± 0.72 μg/mL). Crateva leaves also had the highest anthocyanin content (2.1 g/100 g DM). In conclusion, Crateva adansonii and Capparis corymbosa appear to be promising plant sources, combining nutritional richness and high antioxidant potential. Their integration into the diet could contribute to improving nutritional security and the health of populations. C. corymbosa and C. adansonii contain many nutrients and secondary metabolites and antioxidants. These activities were evaluated by standard methods. These metabolites are a factor in the fight against various diseases.

    Santé publiqueLicence : http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of theLicense, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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  • Article libreArticleEn anglais

    Nutritional perspectives on sickle cell disease in Africa: a systematic review

    Eunice Berko Nartey, Jonathan Spector, Seth Adu-Afarwuah, Catherine L. Jones, Alan Jackson, Agartha Ohemeng, Rajiv Shah, Alice Koryo-Dabrah, Amma Benneh-Akwasi Kuma, Hyacinth I. Hyacinth, Matilda Steiner-Asiedu

    BackgroundSickle cell disease (SCD) is an inherited blood disorder that predominantly affects individuals in sub-Saharan Africa. However, research that elucidates links between SCD pathophysiology and nutritional status in African patients is lacking. This systematic review aimed to assess the landscape of studies in sub-Saharan Africa that focused on nutritional aspects of SCD, and highlights gaps in knowledge that could inform priority-setting for future research.MethodsThe study was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Inclusion criteria comprised original, peer-reviewed research published between January 1995 and November 2020 involving individuals in Africa with any phenotypic variant of SCD and at least one nutritional status outcome. Nutritional status outcomes were defined as those that assessed dietary intakes, growth/anthropometry, or nutritional biomarkers. Databases used were Ovid Embase, Medline, Biosis and Web of Science.ResultsThe search returned 526 articles, of which 76 were included in the final analyses. Most investigations (67%) were conducted in Nigeria. Studies were categorized into one of three main categories: descriptive studies of anthropometric characteristics (49%), descriptive studies of macro- or micronutrient status (41%), and interventional studies (11%). Findings consistently included growth impairment, especially among children and adolescents from sub-Saharan Africa. Studies assessing macro- and micronutrients generally had small sample sizes and were exploratory in nature. Only four randomized trials were identified, which measured the impact of lime juice, long-chain fatty acids supplementation, ready-to-use supplementary food (RUSF), and oral arginine on health outcomes.ConclusionsThe findings reveal a moderate number of descriptive studies, most with small sample sizes, that focused on various aspects of nutrition and SCD in African patients. There was a sta

    HématologiePédiatrieLicence : Open Access http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/publicdomain/zero/1.0/ This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as
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  • Article libreArticleEn anglais

    Nutritional Properties and Preventive Potential of Leptadenia hastata (Pers) Decne (Apocynaceae) Against Metabolic Diseases

    Adjaratou Souratié, Crépin I. Dibala, Hemayoro Sama, Roger Dakuyo, Kayaba Kaboré, Abdoudramane Sanou, Mamounata Diao, Mamoudou Hama Dicko

    ABSTRACTOxidative stress is implicated in various age‐related pathologies, including cardiovascular, ocular, and neurodegenerative diseases. Dietary intake of natural antioxidants can bolster the body's defenses against oxidative damage. This study investigated the nutritional and antioxidant potential of Leptadenia hastata leaves, a food and medicinal plant from Burkina Faso. Standard analytical methods were used to study the physicochemical, nutritional and, antioxidant potential of the leaves. Analysis revealed that L. hastata leaves are rich in nutrients. per 100 g, 71.18 ± 1.83 g of dry matter, 6.89 ± 0.065 g of total ash, 1.67 ± 0.02 g of protein, 11.85 ± 0.33 g of sugar and 1.90 ± 0.07 g of lipid, 60.81 ± 2.31 mg of vitamin C. The water content was 82.59 ± 0.45 g per 100 g of dry leaves. The leaves also showed interesting levels of essential amino acids, including lysine (9.17%), leucine (8.51%), valine (5.61%), phenylalanine (5.29%) and isoleucine (4.44%). In addition, L. hastata leaves showed interesting lycopene (2.70 ± 0.08 mg lycopene/100 mg DM) and β‐carotene (2.99 ± 0.09 mg β‐carotene/100 mg DM) contents. Total phenol content varied from 13.95 ± 0.61 to 36.21 ± 1.88 mg EAG/100 mg while total flavonoid content varied from 0.42 ± 0.11 to 1.95 ± 0.09 mg EQ/100 mg fraction. The ethyl acetate fraction showed the highest concentration of these compounds. Furthermore, the leaves demonstrated strong antioxidant activity in DPPH and FRAP assays, correlating with their phenolic content. These findings suggest that Leptadenia hastata is a valuable source of nutrients, bioactive compounds, and natural antioxidants. Its potential as a dietary supplement for combating oxidative stress‐related diseases warrants further exploration. Leptadenia hastata leaves are rich in essential amino acids, vitamin C, β‐carotene, and lycopene. The ethyl acetate fraction showed the highest antioxidant activity, with strong DPPH and FRAP values correlated with phenolic content. These

    Pharmacognosie, phytothérapie et médecine traditionnelleMédecine interne (cardiologie, endocrinologie, néphrologie…)Santé publiqueLicence : http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of theLicense, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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  • Article libreArticleEn anglais

    Nutritional status in young children prior to the malaria transmission season in Burkina Faso and Mali, and its impact on the incidence of clinical malaria

    Mariken de Wit, Matthew Cairns, Yves Daniel Compaoré, Issaka Sagara, Irene Kuepfer, Issaka Zongo, Amadou Barry, Modibo Diarra, Amadou Tapily, Samba Coumare, Ismaila Thera, Frederic Nikiema, R. Serge Yerbanga, Rosemonde M. Guissou, Halidou Tinto, Alassane Dicko, Daniel Chandramohan, Brian Greenwood, Jean Bosco Ouedraogo

    BackgroundMalaria and malnutrition remain major problems in Sahel countries, especially in young children. The direct effect of malnutrition on malaria remains poorly understood, and may have important implications for malaria control. In this study, nutritional status and the association between malnutrition and subsequent incidence of symptomatic malaria were examined in children in Burkina Faso and Mali who received either azithromycin or placebo, alongside seasonal malaria chemoprevention.MethodsMid-upper arm circumference (MUAC) was measured in all 20,185 children who attended a screening visit prior to the malaria transmission season in 2015. Prior to the 2016 malaria season, weight, height and MUAC were measured among 4149 randomly selected children. Height-for-age, weight-for-age, weight-for-height, and MUAC-for-age were calculated as indicators of nutritional status. Malaria incidence was measured during the following rainy seasons. Multivariable random effects Poisson models were created for each nutritional indicator to study the effect of malnutrition on clinical malaria incidence for each country.ResultsIn both 2015 and 2016, nutritional status prior to the malaria season was poor. The most prevalent form of malnutrition in Burkina Faso was being underweight (30.5%; 95% CI 28.6–32.6), whereas in Mali stunting was most prevalent (27.5%; 95% CI 25.6–29.5). In 2016, clinical malaria incidence was 675 per 1000 person-years (95% CI 613–744) in Burkina Faso, and 1245 per 1000 person-years (95% CI 1152–1347) in Mali. There was some evidence that severe stunting was associated with lower incidence of malaria in Mali (RR 0.81; 95% CI 0.64–1.02; p = 0.08), but this association was not seen in Burkina Faso. Being moderately underweight tended to be associated with higher incidence of clinical malaria in Burkina Faso (RR 1.27; 95% CI 0.98–1.64; p = 0.07), while this was the case in Mali for moderate wasting (RR 1.27; 95% CI 0.98–1.64; p = 0.07). However, these asso

    Parasitologie et mycologieMaladies infectieuses et tropicalesPédiatrieLicence : Open Access http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/publicdomain/zero/1.0/ This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as
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  • Article libreArticleEn anglais

    Nutritional status of children under five years and associated factors in 24 districts of Burkina Faso

    Malnutrition in children is a serious health problem, especially in Sub-Saharan Africa, with heavy socioeconomic burdens. The prevalence of stunting remains high in Burkina Faso. There is a need to further investigate undernutrition and identify the major factors contributing to its persistence. We aimed to assess the nutritional status of children aged under five years and the associated factors of undernutrition in Burkina Faso. We conducted a second study using a baseline household survey of the impact assessment of a performance-based financing program. The analysis focused on data of 10,032 children aged 0–59 months collected from households in 537 villages. Anthropometric indicators were assessed using the World Health Organization standards, and their association with children, mothers, and households’ characteristics were assessed using logistic regression. Stunting occurred in 40.1% of children, wasting in 25.1%, and underweight in 34%. Children having both stunting, wasting, and underweight were 7.3%. Stunting and underweight was associated with the sex. Stunting was associated with ethnic groups: Fulani with AdjOR = 1.20 (95%CI: 1.01–1.42), household economic level: poorest AdjOR = 1.25 (95%CI: 1.10–1.43), two and more children aged under five years in households: AdjOR = 1.16 (95%CI: 1.05–1.27), distance more than 5km from household to health facility: with Adj OR = 1.21 (95%CI: 1.10–1.35) and household food insecurity. This study identified the modifiable factors that determine the high prevalence of undernutrition in Burkina Faso. Strategies and interventions to improve the health and economic status of the community are needed to reduce the occurrence of undernutrition.

    Biostatistiques et épidémiologiePédiatrieSanté publiqueLicence : Creative Commons Attribution License This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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  • Article libreArticleEn anglais

    Nutritional Status of Patients with Tuberculosis and Associated Factors in the Health Centre Region of Burkina Faso

    Beatrice B. Musuenge, Ghislain G. Poda, Pei-Chun Chen

    Extreme hunger and poverty remain a significant barrier to maintaining a normal and healthy life, and increase the burden of tuberculosis (TB) in sub-Saharan African countries. The purpose of this study was to assess the prevalence and factors associated with undernutrition among adult patients with TB in Burkina Faso. In the Health Centre Region of Burkina Faso, we conducted a cross-sectional survey with face-to-face interviews of patients aged 15 years and older with TB (n = 302), from March to April 2019. Undernutrition was defined as a body mass index of <18.5 kg/m2. Multiple logistic regression analyses were performed to determine the correlates of undernutrition. The prevalence of undernutrition was 35.8%, in which severe, moderate, and mild thinness were 7.7%, 8.9%, and 19.5%, respectively. Low food frequency per day (adjusted odds ratio [aOR] = 3.28, confidence interval [CI]: 1.42–7.55, p = 0.005), human immunodeficiency virus infection (aOR = 6.18, CI: 2.26–16.88, p < 0.001), and diabetes mellitus (aOR = 17.52, 95% CI: 1.88–162.97, p = 0.012) and young age (45–54 years vs. 65 years and older, aOR = 2.93, 95% CI: 1.11–7.70, p = 0.029) were associated with increased odds of undernutrition. We concluded that the assessment of comorbidity and nutritional status should be part of the treatment for adult TB patients.

    Biostatistiques et épidémiologieMicrobiologie (bactériologie, virologie)ImmunologieLicence : http://creativecommons.org/licenses/by/4.0/ Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ().
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  • Article libreArticle

    Obésité abdominale et autres biomarqueurs de risque cardiométabolique: influence du niveau socioéconomique et du mode de vie dans deux populations noires apparentées, Cotonou (Bénin) et Port-au-Prince (Haïti)

    Asma EL Mabchour, Hélène Delisle, Colette Vilgrain, Phillipe Larco, Roger Sodjinou

    IntroductionL’augmentation du risque cardio-métabolique (RCM) dans les pays à faible et à moyen revenu résulte pour large part d’une transition nutritionnelle rapide. Cette étude est réalisée dans deux groupes de population apparentés mais vivant dans des environnements différents. Elle vise à cerner la relation entre le mode de vie et les biomarqueurs de RCM, ainsi qu’entre l’obésité abdominale (OA) et les autres biomarqueurs.MéthodesL’étude porte sur 200 Béninois de Cotonou et 252 Haïtiens de Port-au-Prince (PAP) âgés de 25 à 60 ans et apparemment en bonne santé. L’OA est définie spécifiquement par un tour de taille (TT) ≥ 88cm (hommes) et ≥ 95cm (femmes). Les autres biomarqueurs les plus fréquents sont considérés: un ratio cholestérol total/HDL-cholestérol élevé, une tension artérielle élevée et la résistance à l’insuline d’après HOMA (Homeostasis Model Assessement). Le niveau socio-économique (NSE), l’alimentation, la consommation d’alcool et de tabac sont documentés par questionnaire. Deux schémas alimentaires ressortent de l’analyse typologique, l’un traditionnel et l’autre « transitionnel », avec une fréquence accrue d’aliments occidentaux.RésultatsLe NSE, la consommation d’alcool et le tabagisme sont associés au RCM, mais non le schéma alimentaire. L’OA est associée aux autres biomarqueurs de RCM, sans effet marqué du NSE et des variables du mode de vie.ConclusionLes valeurs-seuilsspécifiques de TT se confirment. Aussi, le NSE et le mode de vie influencent le RCM mais non la relation entre l’OA et les autres biomarqueurs de RCM.

    Microbiologie (bactériologie, virologie)PharmacologieMédecine interne (cardiologie, endocrinologie, néphrologie…)Licence : The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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  • Article libreArticle

    Obésité de l’adolescent à Abidjan: prévalence et facteurs associés-résultats d’une enquête en milieu scolaire dans la commune de Koumassi

    Tiépé Rokia Ouattara, Hervé Micondo, Franck Kouassi, Félicia Akousssi, Adelaïde Hue-Lou, Jocelyne Danho, Anselme N'guessan, Assita Yao, Kevin Acho, Jacko Rhedoor Abodo

    Peu d'études ont été consacrées à l'obésité du sujet jeune dans notre contexte malgré sa prévalence croissante. L'objectif de notre étude était donc de déterminer la prévalence et les facteurs associés à l'obésité de l'adolescent en milieu scolaire. Nous avons réalisé une étude multicentrique transversale au sein de quatre écoles dans la commune de Koumassi lors de la visite médicale des élèves. Ceux ayant des valeurs de l'indice de masse corporelle (IMC) supérieurs à 25kg/m2 ou ayant une courbe IMC/âge au-delà de IOTF 30 étaient retenus. La collecte des données s'est faite à l'aide d'un questionnaire et l'analyse statistique réalisé à l'aide du logiciel SPSS. Le test statistique utilisé était le test du Khi-deux (significativité P= 0,05). Au total 94 élèves avaient été recrutés soit une prévalence de 1,82% de surcharge pondérale. Il existait une prédominance féminine (73%) avec un sex ratio de 0,36 et un pic de prévalence entre 12 et 14 ans. Dans les antécédents, l'on notait que 16% des enfants avaient au moins un parent atteint d'obésité avec un niveau socio-économique bas dans 44% des cas. L'obésité était de grade I dans 45,7% des cas et le nombre moyen des repas était de deux repas quotidiens. Une activité sportive extrascolaire chez 41,5% des élèves. Les facteurs associés à la survenue de l'obésité étaient le sexe féminin (0,01), l'âge (0,02), le tour de taille (0,003) et le tour de hanche (0,005). L'obésité est une réalité en milieu scolaire. La lutte contre cette affection implique nécessairement une modification du style de vie combiné à l'action de divers acteurs de la santé publique.

    Biostatistiques et épidémiologiePédiatrieSanté publiqueLicence : https://creativecommons.org/licenses/by/4.0/ The Pan African Medical Journal (ISSN: 1937-8688). This is an Open Access article distributed under the terms of the Creative Commons Attribution International 4.0 License (), which permits unrestricted use, distribution, and reproduction in any medium, p
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  • Article libreArticle

    Obésité, activité physique et temps de sédentarité chez des adolescents scolarisés, âgés de 15 à 18 ans de la ville de Sfax (Tunisie)

    Sofien Regaieg, Nadia Charfi, Mouna Elleuch, Fatma Mnif, Rim Marrakchi, Sourour Yaich, Kamel Jammousi, Jamel Damak, Mohamed Abid

    IntroductionLe but de notre étude était d’évaluer la prévalence du surpoids et de l'obésité chez des adolescents scolarisés dans la ville de Sfax mais aussi, d’étudier son association avec le temps de sédentarité et l'activité physique (AP).MéthodesLa population étudiée était composée de 1695 adolescents âgés de 15-18 ans. Tous les participants avait rempli un questionnaire porté sur leurs activités physiques et temps de sédentarité, donné lors d'un entretien direct. Le niveau d'AP était évalué avec l'International Physical Activity Questionnaire (IPAQ) version courte.RésultatsNotre étude comportait 43,7% de garçons et 56,3% de filles. L’âge moyen était de 16,78 ± 1, 1 an. Dans notre échantillon, 23,4% des adolescents étaient en surpoids ou obèses. Le score de l'IPAQ nous a montré que le niveau d'AP de nos participants était faible dans 6,4%, modéré dans 65,4% et élevé dans 28,2% des cas. Nos résultats avaient démontré que l'augmentation du temps de sédentarité (plus de 2 h / jour) est associée à une augmentation significative de l'indice de masse corporelle (IMC) et du tour de taille (TT) (P <0,001). Alors qu'un niveau d'AP élevé et/ou la participation aux séances d'AP structurées dans le cadre scolaire et hors scolaire est accompagnée par une diminution significative de l'IMC et du TT (P <0,001).ConclusionNos résultats apportent une preuve supplémentaire sur la nécessité de promouvoir la vie active chez les jeunes Tunisiens.

    Biostatistiques et épidémiologieSanté publiqueLicence : The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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  • Article libreArticleEn anglais

    Obesity phenotypes and dyslipidemia in adults from four African countries: An H3Africa AWI-Gen study

    IntroductionThe contribution of obesity phenotypes to dyslipidaemia in middle-aged adults from four sub-Saharan African (SSA) countries at different stages of the epidemiological transition has not been reported. We characterized lipid levels and investigated their relation with the growing burden of obesity in SSA countries.MethodsA cross-sectional study was conducted in Burkina Faso, Ghana, Kenya and South Africa. Participants were middle aged adults, 40–60 years old residing in the study sites for the past 10 years. Age-standardized prevalence and adjusted mean cholesterol, LDL-C, HDL-C, triglycerides and non-HDL-C were estimated using Poisson regression analyses and association of body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WTHR) with abnormal lipid fractions modeled using a random effects meta-analysis. Obesity phenotypes are defined as BMI ≥ 30 kg/m2, increased WC and increased waist-to-hip ratio.ResultsA sample of 10,700 participants, with 54.7% being women was studied. Southern and Eastern African sites recorded higher age-standardized prevalence of five lipid fractions then West African sites. Men had higher LDL-C (19% vs 8%) and lower HDL-C (35% vs 24%) while women had higher total cholesterol (15% vs 19%), triglycerides (9% vs 10%) and non-HDL-cholesterol (20% vs 26%). All lipid fractions were significantly associated with three obesity phenotypes. Approximately 72% of participants in the sample needed screening for dyslipidaemia with more men than women requiring screening.ConclusionObesity in all forms may drive a dyslipidaemia epidemic in SSA with men and transitioned societies at a higher risk. Targeted interventions to control the epidemic should focus on health promoting and improved access to screening services.

    Biostatistiques et épidémiologieSanté publiqueLicence : Creative Commons Attribution License This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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  • Article libreArticle

    Observance de l’hygiène des mains dans les hôpitaux généraux de référence de la ville de Kisangani en République Démocratique du Congo

    Eugène Basandja Longembe, Panda Lukongo Kitronza

    Introductionla présente étude avait pour objectif d’évaluer le niveau de l’observance de l’hygiène des mains par les professionnels de santé des Hôpitaux Généraux de Référence (HGR) de la ville de Kisangani et d’identifier les facteurs déterminants.Méthodesune étude transversale est menée dans les services de maternité, chirurgie, pédiatrie et urgences des quatre HGR de la ville de Kisangani pendant la période du 13 au 20 juin 2018. Un questionnaire auto-administré a été remis à 120 professionnels de santé recrutés parmi les médecins, infirmiers, techniciens de laboratoire et garçons et filles de salle pour évaluer leur niveau de connaissance et une grille d’observation de l’hygiène des mains utilisée sur 44 prestataires pour 1920 opportunités.Résultatsle taux d’observance global de l’hygiène des mains est de 39% [IC95 0,37; 0,41]; la friction avec la solution hydro alcoolique est beaucoup moins fréquente (5%); les techniciens de surface et les médecins ont présenté des taux d’observance plus élevés respectivement 49% et 44% que les infirmiers (33%). Environ un tiers de professionnels connaissent les indications de l’hygiène des mains selon l’OMS; 37% de prestataires ont déclaré avoir suivi une formation en cours d’emploi sur l’hygiène des mains et 36% connaissent l’importance de l’hygiène des mains en milieu de soin. La différence de connaissance n’est pas significative entre les catégories professionnelles étudiées (p > 0,05).Conclusioncette étude nous a permis à travers les résultats obtenus de conclure que le niveau d’observance des précautions standards en hygiène des mains par les professionnels de santé reste insuffisant. Il s’avère donc nécessaire de renforcer l’observance de l’hygiène des mains par les programmes de formation et de sensibilisation des professionnels de santé, l’approvisionnement en produits d’hygiène et la prise de conscience des prestataires de soins.

    PédiatrieGynécologie-obstétriqueLicence : The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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  • Article libreArticle

    Observance de la deuxième et de la troisième dose de la chimioprévention du paludisme saisonnier chez les enfants de 3 à 59 mois et 6-9 ans dans la commune de Guidimouni, Niger

    Almoustapha Mahamane Wazodan, Mahaman Moustapha lamine, Mahamadou Doutchi, Lawali Ali Ismael, Ibrahim Alkassoum, Léon Blaise Gwendé Savadogo, Eric Adehossi

    Introductionla chimioprévention du paludisme saisonnier (CSP) est une stratégie efficace pour prévenir le paludisme. En 2022, le programme national de lutte contre le paludisme du Niger a décidé de faire l'extension de la CPS aux enfants de 6 à 9 ans et à cinq cycles. L'objectif de l'étude était de déterminer les facteurs influençant l'observance des deuxièmes et troisièmes doses de la CPS dans le contexte de son extension à Guidimouni, Zinder.Méthodesdes groupes de discussions ont été organisés avec des mères gardiennes d'enfants; des relais communautaires et des entretiens approfondis ont été menés avec des soignants et des autorités administratives et coutumières. Les entretiens ont été enregistrés et transcrits, ceux dans les langues locales traduits en français et les transcriptions analysées à l'aide du logiciel N'Vivo.Résultatsau total, neuf groupes de discussion et six entretiens individuels ont été réalisés. La CPS avec extension était largement acceptée comme une mesure préventive clé. L'observance de la CPS chez les parents des enfants de 3 à 5 ans et 6-9 ans semble être généralement bonne, ce qui signifie qu'ils sont en général conformes à la prise de la 2e et de la 3e dose. Les facteurs clés influençant l'observance sont: la mauvaise application des consignes d'administration, l'utilisation des médicaments de la CPS pour traiter d'autres maladies, la réserve d'une partie importante du médicament, ce qui peut affecter la dose seuil à la prévention et la perception de la CPS comme un traitement curatif plutôt que préventif du paludisme. La prévalence du paludisme chez les enfants de moins de 5 ans et les enfants ayant l'âge supérieur à 10 ans sont respectivement 32,03% et 35,68 en 2019; 46,76% et 37,11% en 2020, 53,07% et 49,09% en 2021, 51,93% et 45,92 en 2022. L'évolution des cas du paludisme dans cette tranche d'âge dans le village de Guidimouni ne fait qu'augmenter et présente une prévalence importante à l'égard de cette communauté malgré la chimiopré

    Biostatistiques et épidémiologieParasitologie et mycologiePharmacologieLicence : https://creativecommons.org/licenses/by/4.0/ The Pan African Medical Journal (ISSN: 1937-8688). This is an Open Access article distributed under the terms of the Creative Commons Attribution International 4.0 License (), which permits unrestricted use, distribution, and reproduction in any medium, p
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  • Lien vers la sourceMémoire

    Observance parentale chez l’enfant pied bot varus équin : étude des stratégies éducatives mises en place par les kinésithérapeutes

    Carla Gregorini

    Le pied bot varus équin (PBVE) est une déformation congénitale fréquente prise en charge par la méthode fonctionnelle ou la méthode Ponseti. Or, malgré l’efficacité du traitement, nous observons un risque de rechute élevé, lié à un manque d’observance du port d’attelle. L’objectif est de comprendre les stratégies éducatives mises en place par les kinésithérapeutes pour favoriser l’observance parentale et limiter les rechutes. Une étude qualitative par entretiens semi-directifs a été effectuée auprès de sept kinésithérapeutes prenant en charge le PBVE. L’analyse de contenu s’est déroulée selon trois niveaux : une analyse catégorielle, fréquentielle et énonciative. Les résultats font émerger plusieurs axes stratégiques : une communication adaptée, répétée et préventive incluant l’utilisation de supports pédagogiques variés et un double soutien apporté par les kinésithérapeutes et les parents entre eux. Le score du kappa de Cohen (0,93) révèle un accord quasi-parfait inter-évaluateurs. Les résultats soulignent l’importance de considérer la triade thérapeutique. Les kinésithérapeutes mettent en place différentes stratégies éducatives basées sur la communication et l’utilisation de supports pédagogiques. Ils favorisent les relations inter parentales pour renforcer le soutien. Ces outils semblent favoriser l’observance parentale. L’intégration de psychologues au parcours de soin et la création d’un support officiel constitueraient des perspectives intéressantes.

    SémiologieMaladies infectieuses et tropicalesMédecine interne (cardiologie, endocrinologie, néphrologie…)Licence : https://creativecommons.org/licenses/by/4.0/
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  • Article libreArticle

    Observance thérapeutique de l’hypertension artérielle et ses facteurs dans le service de cardiologie du CHU Tokoin de Lomé

    Machihude Pio, Soodougoua Baragou, Yaovi Afassinou, Souleymane Pessinaba, Borgatia Atta, Koffi Ehlan, Edem Goeh-Akue, Folly Zoméni, Jean-Marie Damorou

    IntroductionEvaluer l’observance thérapeutique de l’HTA et de déterminer les facteurs de mauvaise observance chez les hypertendus au CHU Tokoin de Lomé.MéthodesNous avons effectué une étude transversale descriptive sur une durée de 6 mois en consultation externe dans le service de Cardiologie du CHU-Tokoin de Lomé. L’étude a concerné 363 patients hypertendus. L’évaluation de l’observance a été effectuée avec le test d’évaluation de l’observance de Girerd.RésultatsLe revenu mensuel était inférieur à 50.000 FCFA chez 49,86% patients; 85,05% des patients n’avaient aucune assurance maladie. Le coût mensuel du traitement par patient était de 10.560 FCFA soit 37,74% du SMIG au Togo. Quatre-vingt et trois virgule soixante-quinze pour cent (83,75%) de nos patients avaient eu des difficultés à observer correctement leur traitement antihypertenseur. Parmi eux 52,34% étaient mauvais observants et 31,41% avaient de minimes problèmes d’observance. Seuls 16,25% étaient de bons observants. Les facteurs de mauvaises observances étaient: le revenu mensuel faible, l’absence d’assurance maladie, le nombre de comprimés et de prises de comprimés supérieurs à 3, et la tradithérapie.ConclusionL’observance thérapeutique a été mauvaise dans notre série. Les facteurs de cette mauvaise observance sont multiples et variés mais dominés pour la plupart par la pauvreté et l’absence d’assurance maladie.

    Médecine interne (cardiologie, endocrinologie, néphrologie…)Licence : The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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