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  • Article libreArticleEn anglais

    Implementation Fidelity of the National Malaria Control Program in Burkina Faso

    BackgroundEvery year 40,000 people die of malaria in Burkina Faso. In 2010, the Burkinabè authorities implemented a national malaria control program that provides for the distribution of mosquito nets and the home-based treatment of children with fever by community health workers. The objective of this study was to measure the implementation fidelity of this program.MethodsWe conducted a case study in two comparable districts (Kaya and Zorgho). Data were collected one year after the program’s implementation through field observations (10 weeks), documentary analysis, and individual interviews with stakeholders (n = 48) working at different levels of the program. The analysis framework looked at the fidelity of (i) the intervention’s content, (ii) its coverage, and (iii) its schedule.ResultsThe program’s implementation was relatively faithful to what was originally planned and was comparable in the two districts. It encountered certain obstacles in terms of the provision of supplies. Coverage fidelity was better in Kaya than in Zorgho, where many community health workers (CHW) experienced problems with the restocking of artemisinin-based combination therapy and with remuneration for periods of training. In both districts, the community was rarely involved in the process of selecting CHWs. The components affected by scheduling all experienced successive implementation delays that pushed nets distribution and the initial provision of artemisinin-based combination therapies to the CHWs past the 2010 malaria season.ConclusionsThe activities intended by the program were mostly implemented with good fidelity. However, the implementation was plagued by delays that probably postponed the expected beneficial effects.

    Parasitologie et mycologieMaladies infectieuses et tropicalesPédiatrieLicence : This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
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  • Lien vers la sourceArticleEn anglais

    Implementation of a decision aid to promote shared decision-making on mode of birth in low-risk pregnant women: a cross-sectional study within the QUALI-DEC hybrid trial

    Truc Phuong Nguyen, Ana Pilar Betran, Guillermo Carroli, Charles Kaboré, Pisake Lumbiganon, Quoc Nhu Hung Mac, Celina Gialdini, Camille Etcheverry, Barbara Vololonarivelo, Kristi Sidney Annerstedt, Ramón Escuriet, Claudia Hanson, Allison Shorten, Alexandre Dumont

    AbstractIntroductionImplementing shared decision-making (SDM) in maternity care remains challenging in low-income and middle-income countries (LMICs). Decision aids can support SDM, but evidence on their effectiveness in such settings is limited. We assessed the impact of a decision analysis tool (DAT) for pregnant women on mode of birth (MOB) within the QUALIty DECision-making project, a multisite, multicountry pragmatic trial to reduce unnecessary caesarean sections.MethodsWe conducted a cross-sectional survey among postpartum women considered at low risk for caesarean section in early pregnancy and who delivered in 32 hospitals across Argentina, Burkina Faso, Thailand and Viet Nam. Associations between DAT exposure and selected outcomes were analysed using multilevel, multivariate regression models adjusting for confounders and cluster effects.ResultsOf 2368 women included, 249 (11%) had used it outside antenatal care visits, 212 (9%) had heard of but not used it, and 1907 (80%) had never heard of the DAT. Compared with women who had never heard of the DAT, users were more likely to identify at least three risks/benefits of each MOB (adjusted OR (aOR) 1.9; 95% CI 1.3 to 2.8; p=0.001) and to communicate their preferred MOB to providers (aOR 2.3; 95% CI 1.5 to 3.6; p<0.001). DAT users were less likely to prefer caesarean section in late pregnancy (aOR 0.4; 95% CI 0.2 to 0.8; p=0.006) and reported higher birth experience and satisfaction scores (adjusted β=1.9; 95% CI 0.5 to 3.3; p=0.006).ConclusionsThe use of the DAT was associated with improved knowledge, communication of birth preferences, lower caesarean preference and greater satisfaction, without adverse outcomes. Findings suggest that decision aids can strengthen SDM and promote respectful, women-centred maternity care in LMICs.Trial registration number ISRCTN67214403

    Biostatistiques et épidémiologieImmunologieMaladies infectieuses et tropicalesLicence : CC BY 3.0 IGO This is an open access article distributed under the terms of the Creative Commons Attribution IGO License (), which permits use, distribution,and reproduction in any medium, provided the original work is properly cited. In any reproduction of this article there should not be any sugge
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  • Article libreArticleEn anglais

    Implementation of a malaria rapid diagnostic test in a rural setting of Nanoro, Burkina Faso: from expectation to reality

    Francois Kiemde, Marc Christian Tahita, Massa dit Achille Bonko, Petra F. Mens, Halidou Tinto, Michael Boele van Hensbroek, Henk D. F. H. Schallig

    BackgroundMalaria rapid diagnostic tests (RDTs) are nowadays widely used in malaria endemic countries as an alternative to microscopy for the diagnosis of malaria. However, quality control of test performance and execution in the field are important in order to ensure proper use and adequate diagnosis of malaria. The current study compared the performance of a histidine-rich protein 2-based RDT used at peripheral health facilities level in real life conditions with that performed at central reference laboratory level with strict adherence to manufacturer instructions.MethodsFebrile children attending rural health clinics were tested for malaria with a RDT provided by the Ministry of Health of Burkina Faso as recommended by the National Malaria Control Programme. In addition, a blood sample was collected in an EDTA tube from all study cases for retesting with the same brand of RDT following the manufacturer’s instructions with expert malaria microscopy as gold standard at the central reference laboratory. Fisher exact test was used to compare the proportions by estimating the p-value (p ≤ 0.05) as statistically significant.ResultsIn total, 407 febrile children were included in the study and malaria was diagnosed in 59.9% (244/407) of the cases with expert malaria microscopy. The sensitivity of malaria RDT testing performed at health facilities was 97.5% and comparable to that achieved at the laboratory (98.8%). The number of malaria false negatives was not statistically significant between the two groups (p = 0.5209). However, the malaria RDT testing performed at health facilities had a specificity issue (52.8%) and was much lower compared to RDT testing performed at laboratory (74.2%). The number of malaria false positives was statistically significantly different between the two groups (p = 0.0005).ConclusionMalaria RDT testing performed at the participating rural health facilities resulted in more malaria false positives compared to those performed at central labo

    Parasitologie et mycologieMaladies infectieuses et tropicalesPédiatrieLicence : Open Access http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/publicdomain/zero/1.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (), which permits unrestricted use, distribution, and reproduction in any medium, provid
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  • Article libreArticleEn anglais

    Implementation of a Prospective Birth Cohort for Newborn Screening and Early Linkage to Comprehensive Sickle Cell Disease Care in a Low-Resource Setting

    In sub-Saharan Africa, where approximately 75% of newborns with sickle cell disease (SCD) are born, under-five mortality remains high, partly due to the absence of newborn screening (NBS) and delayed linkage to comprehensive care. We conducted a prospective, quasi-experimental study involving two sequential newborn screening cohorts at Aminu Kano Teaching Hospital (AKTH), Kano, Nigeria (December 2022–December 2025), to evaluate the feasibility of integrating newborn screening (NBS) with early comprehensive SCD care and to identify barriers to enrollment before 3 months of age. Following an initial implementation period with suboptimal follow-up, a structured family-centered enrollment and communication strategy was introduced to improve early linkage to comprehensive care. During the pre-intervention period, 277 newborns were enrolled (33 with SCD and 244 without SCD [NSCD]), with early enrollment (≤3 months) occurring in 46.5% overall, higher among SCD than NSCD infants (72.8% vs. 43.0%). Delayed enrollment (>6 months) was more frequent among SCD infants. Following the implementation of family-centered communication strategies, 60 additional newborns were enrolled (16 SCD, 44 NSCD), and early enrollment increased to 91.7%. These findings demonstrate that low-cost, family-centered communication and tracking strategies can substantially improve early linkage to comprehensive SCD care following newborn screening in low-resource settings. Early enrollment is a critical step toward reducing morbidity and mortality among children with SCD in low-resource settings.

    Biostatistiques et épidémiologieHématologiePédiatrieLicence : Creative Commons Attribution (CC BY) license Published by MDPI on behalf of the International Society for Neonatal Screening. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the.
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  • Article libreArticleEn anglais

    Implementation of Home based management of malaria in children reduces the work load for peripheral health facilities in a rural district of Burkina Faso

    Alfred B Tiono, Youssouf Kaboré, Abdoulaye Traoré, Nathalie Convelbo, Franco Pagnoni, Sodiomon B Sirima

    BackgroundHome Management of Malaria (HMM) is one of the key strategies to reduce the burden of malaria for vulnerable population in endemic countries. It is based on the evidence that well-trained communities health workers can provide prompt and adequate care to patients close to their homes. The strategy has been shown to reduce malaria mortality and severe morbidity and has been adopted by the World Health Organization as a cornerstone of malaria control in Africa. However, the potential fall-out of this community-based strategy on the work burden at the peripheral health facilities level has never been investigated.MethodsA two-arm interventional study was conducted in a rural health district of Burkina Faso. The HMM strategy has been implemented in seven community clinics catchment's area (intervention arm). For the other seven community clinics in the control arm, no HMM intervention was implemented. In each of the study arms, presumptive treatment was provided for episodes of fevers/malaria (defined operationally as malaria).The study drug was artemether-lumefantrine, which was sold at a subsidized price by community health workers/Key opinion leaders at the community level and by the pharmacists at the health facility level.The outcome measured was the proportion of malaria cases among all health facility attendance (all causes diseases) in both arms throughout the high transmission season.ResultsA total of 7,621 children were enrolled in the intervention arm and 7,605 in the control arm. During the study period, the proportions of malaria cases among all health facility attendance (all causes diseases) were 21.0%, (445/2,111, 95% CI [19.3%–22.7%]) and 70.7% (2,595/3,671, 95% CI 68.5%–71.5%), respectively in the intervention and control arms (p << 0.0001). The relative risk ratio for a fever/malaria episode to be treated at the HF level was 30% (0.30 < RR < 0.32).The number of malaria episodes treated in the intervention arm was much higher than in the cont

    Parasitologie et mycologiePharmacologieMaladies infectieuses et tropicalesLicence : This is an Open Access article distributed under the terms of the Creative Commons Attribution License (), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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  • Article libreArticleEn anglais

    Implementation of HPV-based screening in Burkina Faso: lessons learned from the PARACAO hybrid-effectiveness study

    Keitly Mensah, Charles Kaboré, Salifou Zeba, Magali Bouchon, Véronique Duchesne, Dolorès Pourette, Pierre DeBeaudrap, Alexandre Dumont

    BackgroundCervical cancer screening in sub-Saharan countries relies on primary visual inspection with acetic acid (VIA). Primary human papillomavirus (HPV)-based screening is considered a promising alternative. However, the implementation and real-life effectiveness of this strategy at the primary-care level in limited-resource contexts remain under explored. In Ouagadougou, Burkina Faso, free HPV-based screening was implemented in 2019 in two primary healthcare centers. We carried out a process and effectiveness evaluation of this intervention.MethodsEffectiveness outcomes and implementation indicators were assessed through a cohort study of screened women, observations in participating centers, individual interviews with women and healthcare providers and monitoring reports. Effectiveness outcomes were screening completeness and women’s satisfaction. Logistic regression models and concurrent qualitative analysis explored how implementation variability, acceptability by women and the context affected effectiveness outcomes.ResultsAfter a 3-month implementation period, of the 350 women included in the cohort, 94% completed the screening, although only 26% had their screening completed in a single visit as planned in the protocol. The proportion of highly satisfied women was higher after result disclosure (95%) than after sampling (65%). A good understanding of the screening results and recommendations increased screening completeness and women’s satisfaction, while time to result disclosure decreased satisfaction. Adaptations were made to fit healthcare workers’ workload.ConclusionFree HPV-based screening was successfully integrated within primary care in Ouagadougou, Burkina Faso, leading to a high level of screening completeness despite the frequent use of multiple visits. Future implementation in primary healthcare centers needs to improve counseling and reduce wait times at the various steps of the screening sequence.Supplementary InformationThe online version c

    Biologie cellulaire et moléculaireGénétiqueBiostatistiques et épidémiologieLicence : Open Access http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/publicdomain/zero/1.0/ This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as
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  • Article libreArticleEn anglais

    Implementation of lockdown, quarantine, and isolation measures in the context of COVID-19 among internally displaced persons in Burkina Faso: a qualitative study

    Kadidiatou Kadio, Antarou Ly, Adidjata Ouédraogo, Mohamed Ali Ag Ahmed, Sanni Yaya, Marie-Pierre Gagnon

    BackgroundThe triple political, security, and health crisis in Burkina Faso has impacted the lives of Burkinabè people, resulting in massive internal displacement. These internally displaced persons (IDPs) are very vulnerable to epidemic diseases, which was exacerbated by the recent COVID-19 pandemic., The implementation of public health measures to curb the spread of COVID-19 represented a major concern among IDPs. The objective of this study was to document knowledge, difficulties, adjustments, and challenges faced by IDPs and humanitarian authorities/actors during implementation of lockdown, quarantine, and isolation measures in response to COVID-19.MethodsThe study was conducted in Burkina Faso, in the north-central region Kaya, a commune which hosts the largest number of IDPs in the country. Qualitative research using semi-structured interviews collected discursive data from 18 authorities and/or humanitarian actors and 29 IDPs in June 2021. The transcribed interviews were coded with N’vivo 11 software and analyzed thematically.ResultsAlthough respondents had a good knowledge of lockdown, isolation, and quarantine measures, the difference between these three concepts was not easily understood by either authorities/humanitarian actors or IDPs. Communication was one of the biggest challenges for humanitarian actors. The difficulties encountered by IDPs were economic (lack of financial resources), infrastructural (limited housing), and socio-cultural in the application of lockdown, isolation, and quarantine measures. As for adjustment measures, the health authorities developed a strategy for isolation and quarantine for the management of positive and suspected cases. The IDPs mentioned their commitment to compliance and awareness of lockdown measures as the main adjustment.ConclusionAlthough there were no known cases of COVID-19 among the IDPs at the time of the study, tailored response plans were developed to facilitate the application of these measures in emerge

    Santé publiqueLicence : Open Access http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/publicdomain/zero/1.0/ This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as
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  • Article libreArticleEn anglais

    Implementation of the global laboratory leadership programme in Burkina Faso: lessons learned and processes toward sustainability

    Emilie Dama, Abdoulaye Nikiema, Andre Coulibaly, Raoul Karfo, Issaka Yameogo, Fabienne Soudre, Alice Kiba, Charles Sawadogo, Isidore Bonkoungou, Habibata Zerbo, Lila Rahalison, Amanda Balish, Julius Manjengwa, Elie Kabre, Anicet G. Dahourou, Jean Sakande

    IntroductionThe Global Laboratory Leadership Programme (GLLP) aims to foster and mentor current and emerging laboratory leaders to build, strengthen, and support national laboratory systems using a One Health approach. Six organizations, including the US Centers for Disease Control and Prevention, developed GLLP to address gaps in leadership and management skills, particularly in low- and middle-income countries. This work highlights lessons from implementing GLLP in Burkina Faso, including the approach to sustainability.MethodsA participatory implementation model was adopted, engaging key international and national stakeholders across all One Health sectors. From 2021 to 2023, Burkina Faso implemented the full GLLP learning package, which encompasses all nine competencies, projects, and mentoring. Following the completion of the pilot cohort’s training, a sustainability plan was developed, leading to the creation of a University Diploma in Laboratory Leadership and Management (UD-LLM) in 2024, with the training of its first cohort completed in 2025. For both the pilot and the UD-LLM cohorts, a monitoring and evaluation framework was applied throughout the process.ResultsA total of 44 participants from Burkina Faso and Mauritania were trained in both the pilot (18) and the first cohort of the UD-LLM (26). Participants from Burkina Faso (43) were from all One Health sectors and worked in laboratories across 10 institutions (public, private, and military) located in nine of the country’s 13 regions. A total of 117 projects including 10 capstone projects, were completed to address gaps identified at institutional or national levels with support from mentors. A low representation of candidates from the animal and environmental sectors was noted. Overall satisfaction with the training was reported for both cohorts.ConclusionBurkina Faso is the first country in the French-speaking African region with a sustained GLLP full package integrated into a university curriculum. T

    Biostatistiques et épidémiologieSanté publiqueLicence : This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journa
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  • Article libreArticleEn anglais

    Implementation of the WHO core components of an infection prevention and control programme in two sub-saharan African acute health-care facilities: a mixed methods study

    R. Wood, W. Tembele, A. Hema, A. Somé, E. Kinganda-Lusamaki, C. Basilubo, R. Lumembe, N. Alama, G. Mbunsu, A. Zongo, S. Ahuka, J. J. Muyembe, F. Leendertz, T. Eckmanns, G. Schubert, T. Kagoné, S. Makiala, S. Tomczyk

    BackgroundThe coronavirus pandemic again highlighted the need for robust health care facility infection prevention and control (IPC) programmes. WHO guidelines on the core components (CCs) of IPC programmes provides guidance for facilities, but their implementation can be difficult to achieve in resource-limited settings. We aimed to gather evidence on an initial WHO IPC implementation experience using a mixed methods approach.MethodsA five-day training on the WHO IPC CCs was conducted at two reference acute health care facilities in the Democratic Republic of Congo and Burkina Faso. This was accompanied by a three-part mixed-methods evaluation consisting of a: (1) baseline and follow-up survey of participants’ knowledge, attitudes and practices (KAP), (2) qualitative assessment of plenary discussion transcripts and (3) deployment of the WHO IPC assessment framework (IPCAF) tool. Results were analysed descriptively and with a qualitative inductive thematic approach.ResultsTwenty-two and twenty-four participants were trained at each facility, respectively. Baseline and follow-up KAP results suggested increases in knowledge related to the necessity of a dedicated IPC focal person and annual evaluations of IPC training although lack of recognition on the importance of including hospital leadership in IPC training and hand hygiene monitoring recommendations remained. Most participants reported rarely attending IPC meetings or participating in IPC action planning although attitudes shifted towards stronger agreement with the feeling of IPC responsibility and importance of an IPC team. A reocurring theme in plenary discussions was related to limited resources as a barrier to IPC implementation, namely lack of reliable water access. However, participants recognised the importance of IPC improvement efforts such as practical IPC training methods or the use of data to improve quality of care. The facilities’ IPCAF scores reflected a ‘basic/intermediate’ IPC implementation le

    Biostatistiques et épidémiologieSanté publiqueLicence : Open Access http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/publicdomain/zero/1.0/ This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as
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  • Lien vers la sourceArticleEn anglais

    Implementation of tuberculosis prevention for exposed children, Burkina Faso

    Giorgia Sulis, Adjima Combary, Haileyesus Getahun, Saidou Gnanou, Pier Francesco Giorgetti, Arnaud Konseimbo, Susanna Capone, Yohhei Hamada, Annabel Baddeley, Alberto Matteelli

    AbstractObjectiveTo develop and test a simple system for recording and reporting the diagnosis and treatment of latent tuberculosis infection and to compare the effects of passive and active tracing of child contacts on indicators of such infection.MethodsWe revised Burkina Faso’s latent tuberculosis infection register and quarterly tuberculosis reporting form. Subsequently, coverage of the routine screening of contacts, who were younger than five years, for active tuberculosis and the corresponding percentages of such contacts who, if eligible, initiated preventive therapy were measured, nationwide, between 1 April 2016 and 31 March 2017. In 2016, we evaluated indicators of latent tuberculosis infection in the Hauts-Bassins region before and after community health workers had begun the active tracing of contacts who were younger than five years.FindingsIn Burkina Faso, during our study period, 3717 cases of pulmonary tuberculosis and 1166 corresponding contacts who were younger than five years were reported as the result of routine screening and passive contact tracing. The overall contact:index ratio was 0.31 and corresponding screening coverage was 82.0% (956/1166) and proportion of children starting on preventive treatment was 90.5% (852/941). Active tracing in Hauts-Bassins led to a substantially higher contact/index ratio (1.83) and screening coverage (99.3%; 145/146).ConclusionThe newly established recording and reporting system proved feasible and user-friendly and allowed measurement of global indicators of latent tuberculosis infection. Compared with active tracing, passive tracing led to much lower estimates of the numbers of child contacts.

    Microbiologie (bactériologie, virologie)Maladies infectieuses et tropicalesPédiatrieLicence : http://creativecommons.org/licenses/by/3.0/igo/legalcode This is an open access article distributed under the terms of the Creative Commons Attribution IGO License (), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In any r
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  • Article libreArticleEn anglais

    Implementation of universal newborn bloodspot screening for sickle cell disease and other clinically significant haemoglobinopathies in England: screening results for 2005–7

    A Streetly, R Latinovic, K Hall, J Henthorn

    Early results from the National Health Service Sickle Cell and Thalassaemia Screening programme covering the whole of England are reported following the implementation of the national newborn blood-spot screening programme. Of the 13 laboratories performing screening, 10 chose high-performance liquid chromatography as the first screen, with isoelectric focusing as the second confirmatory test. Screening results for April 2005 to March 2007 are presented and include data from all the laboratories screening newborns in England, and almost 1.2 million infants. The screen-positive results show a national birth prevalence of almost 1 in 2000. The birth prevalence in London is five times that of most of the rest of the country. Over 17 000 carriers have been identified. Approximately seven per 1000 samples are reported as post-transfusion with wide ethnic category variation. Given the prevalence of the conditions, and coverage by ethnicity, 3–4 screen-positive cases could be missed each year. National implementation of newborn screening in England has increased the number of children identified with sickle cell disease, in many areas almost doubling the workload. Underascertainment of the condition has allowed a downplaying of the scale of need. It may also have contributed to infant mortality rates in urban areas as babies died without a diagnosis or treatment. The value of a co-ordinated national approach to policy development and implementation is emphasised by the English experience. The programme provides a model for Europe as well as other countries with significant minority populations, such as Canada. Potentially it also offers important lessons for Africa where the World Health Organization is supporting the introduction of newborn screening.

    Biostatistiques et épidémiologieHématologiePédiatrieLicence : This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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  • Article libreArticleEn anglais

    Implementation research evidence uptake and use for policy-making

    Ulysses Panisset, Tracey Pérez Koehlmoos, Ahmad Hamdi Alkhatib, Tomás Pantoja, Prabal Singh, Jane Kengey-Kayondo, Ben McCutchen, Miguel Ángel González Block

    A major obstacle to the progress of the Millennium Development Goals has been the inability of health systems in many low- and middle-income countries to effectively implement evidence-informed interventions. This article discusses the relationships between implementation research and knowledge translation and identifies the role of implementation research in the design and execution of evidence-informed policy. After a discussion of the benefits and synergies needed to translate implementation research into action, the article discusses how implementation research can be used along the entire continuum of the use of evidence to inform policy. It provides specific examples of the use of implementation research in national level programmes by looking at the scale up of zinc for the treatment of childhood diarrhoea in Bangladesh and the scaling up of malaria treatment in Burkina Faso. A number of tested strategies to support the transfer of implementation research results into policy-making are provided to help meet the standards that are increasingly expected from evidence-informed policy-making practices.

    Parasitologie et mycologieMaladies infectieuses et tropicalesPédiatrieLicence : http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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  • Article libreArticle

    Implementation research for today's HIV response: from theory to applied insights

    Bohdan Nosyk, Eleanor Magongo Namusoke, Anne Trolard, Elvin H. Geng

    ImmunologieMaladies infectieuses et tropicalesLicence : http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of theLicense, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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  • Article libreArticleEn anglais

    Implementation science research for the scale-up of evidence-based interventions for sickle cell disease in africa: a commentary

    Joyce Gyamfi, Temitope Ojo, Juliet Iwelunmor, Gbenga Ogedegbe, Nessa Ryan, Amy Cohen, Obiageli Nnodu, Ambroise Wonkam, Charmaine Royal, Emmanuel Peprah

    BackgroundThe burden of sickle cell disease (SCD) is greatest among African nations. Effective scalability of evidence-based interventions (e.g., newborn screening, health education, prophylaxis for infection, optimal nutrition and hydration, hydroxyurea therapy, blood transfusions, and transcranial Doppler (TCD) screening) is urgently needed particularly in these settings for disease management. However, Africa is constrained by limited resources and the lack of capacity to conduct implementation science research for proper understanding of context, and assessment of barriers and facilitators to the uptake and scalability of evidence-based interventions (EBI) for SCD management.Main BodyWe outline implementation science approaches to embed EBI for SCD within the African context and highlight key implementation research programs for SCD management. Building implementation research capacity will meet the major need of developing effective life-long and accessible locally-tailored interventions for patients with SCD in Africa.ConclusionThis commentary communicates the importance of the application of implementation science methodology to scale-up evidence-based interventions for the management of SCD in order to reduce pain, prevent other morbidities and premature death experienced by people with SCD in Africa, and improve their overall quality of life.

    HématologieLicence : Open Access http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/publicdomain/zero/1.0/ This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as
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  • Article libreArticleEn anglais

    Implementation Status of Low-Dose Aspirin and Calcium Supplementation to Prevent Preeclampsia in Burkina Faso, Ethiopia, Kenya, Nigeria and Pakistan

    Patricia S. Coffey, Kimberly Mansen, Nesibu Agonafir, Gbenga Ishola, Basilia Coefe Nitiema, Megan E. Parker, Soha Randhawa, Janet Shauri, Katharine D. Shelley

    PurposeHypertensive disorders of pregnancy are a leading cause of maternal death. Global guidance recommends use of low-dose aspirin and calcium supplementation for prevention of preeclampsia. Published literature showcasing the implementation of these guidelines in low- and middle-income countries (LMICs) is sparse.DescriptionThe objective of this practice note is to share our findings related to implementation of low-dose aspirin and calcium supplementation for the prevention of preeclampsia in Burkina Faso, Ethiopia, Kenya, Nigeria and Pakistan. The experiences from these five countries can illustrate important aspects about the nature and scope of scale of these two evidence-based interventions in LMICs.AssessmentBetween May 2023 and March 2024, we conducted policy review and key informant interviews (n = 59) at global and country level. Implementation efforts for the two interventions show variations in the policy environment and clinical practices across countries. Progress toward scale of low-dose aspirin is hampered by variable clinical practices, low provider and community awareness, late antenatal care attendance, and under resourced health systems including weak supply chains. In the case of calcium supplementation, a complicated regimen and conditional global recommendations leaves countries without actionable plans aligning with optimal counseling models for improved adherence.ConclusionEffective implementation of low-dose aspirin and calcium supplementation for preeclampsia prevention will require strengthening antenatal care and provision of services at the primary health care level and enabling the policy environment where needed. Increased coordination around a package of interventions aimed at reducing preeclampsia will also be critical going forward. Practice recommendations on policy, demand, clinical implementation, and monitoring are summarized.Supplementary InformationThe online version contains supplementary material available at 10.1007/s109

    Médecine interne (cardiologie, endocrinologie, néphrologie…)Gynécologie-obstétriqueSanté publiqueLicence : Open Access http://creativecommons.org/licenses/by/4.0/ This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original autho
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  • Article libreArticleEn anglais

    Implementation strategies for the introduction of the RTS,S/AS01 (RTS,S) malaria vaccine in countries with areas of highly seasonal transmission: workshop meeting report

    Corinne S. Merle

    A workshop on implementation strategies for the introduction of the RTS,S/AS01 (RTS,S) malaria vaccine in countries with areas of highly seasonal transmission, was held as a hybrid meeting in Dakar, Senegal, and online, 23–25 January 2023. Delegates from Expanded Programmes on Immunization (EPI) and National Malaria Control Programmes (NMCPs) from 13 African countries, and representatives from key stakeholders participated. RTS,S is the first malaria vaccine to be recommended by the World Health Organization (WHO). The recommendation followed pilot implementation of the vaccine in Ghana, Kenya and Malawi, which showed that introduction of the vaccine was highly effective at scale, and was associated with a 30% reduction in hospital admissions with severe malaria in age groups eligible to have received the vaccine and no evidence of the safety signals that had been observed in the phase 3 trial. Clinical trials in Mali and Burkina Faso, showed that in children receiving Seasonal Malaria Chemoprevention (SMC), providing the vaccine just prior to high transmission seasons, matching the period of highest efficacy to the peak transmission season, resulted in substantial reduction in the incidence of clinical malaria and of severe malaria. While SMC has been successfully scaled-up despite the challenges of delivery, there is no established platform for seasonal vaccine delivery and no real-world experience. The objectives of this workshop were, therefore, to share experiences from countries that have introduced the RTS,S vaccine in routine child vaccination programmes, with SMC-implementing countries as they consider malaria vaccine introduction, and to explore implementation strategies in countries with seasonal transmission and where EPI coverage may be low especially in the second year of life. Practical implementation challenges, lessons learned for vaccine introduction, and research questions, towards facilitating the introduction of the RTS,S (and other malaria vacc

    Parasitologie et mycologieImmunologieMaladies infectieuses et tropicalesLicence : Open Access http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/publicdomain/zero/1.0/ This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as
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  • Article libreArticleEn anglais

    Implementing a smoke-free generation policy for Canada: estimates of the long-term impacts

    Doug Coyle

    AbstractIntroduction:The aim of this study was to assess the potential impacts of the introduction of a smoke-free generation (SFG) policy in Canada with a perpetual ban on cigarette sales to anyone born after 2009 instigated on 1 January 2025.Methods:An existing Canadian model relating to smoking cessation was adapted and augmented to assess the impact of an SFG policy on quality-adjusted life years (QALYs), life expectancy, health care costs, smoking-related taxes, and Canadian tobacco industry gross domestic product (GDP). The cumulative impact of the policy for the entire Canadian population was assessed for time horizons up to 90 years with an annual discount rate of 1.5%.Results:After 50 years, this SFG policy would lead to 476814 more QALYs, $2.3 billion less in health care costs, $7.4 billion less in smoking-related taxes and a $3.1 billion reduction in tobacco industry GDP. The combined value of health benefits gained and health care costs averted would exceed the sum of tax revenues foregone and reduced GDP, if the value of a QALY was at least $17147. Use of higher discount rates and inclusion of unrelated health care costs had little impact on the interpretation of the results.Conclusion:The implementation of an SFG policy will bring substantive health benefits to the population in Canada. Although health care cost savings are lower than the combination of lost tax revenues and the decline in the GDP from the Canadian tobacco industry, the value of the health benefits realized outweigh the negative offsets.

    Licence : This work is licensed under a Creative Commons Attribution 4.0 International License
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  • Article libreArticleEn anglais

    Implementing newborn screening for sickle cell disease as part of immunisation programmes in Nigeria: a feasibility study

    Obiageli E Nnodu, Alayo Sopekan, Uche Nnebe-Agumadu, Chinatu Ohiaeri, Adeyemi Adeniran, Grace Shedul, Hezekiah A Isa, Olumide Owolabi, Reuben I Chianumba, Yohanna Tanko, Juliet H Iyobosa, Adekunle D Adekile, Olufunmilayo I Olapade, Frédéric B Piel

    SummaryBackgroundSickle cell disease is highly prevalent in sub-Saharan Africa, where it accounts for substantial morbidity and mortality. Newborn screening is paramount for early diagnosis and enrolment of affected children into a comprehensive care programme. Up to now, this strategy has been greatly impaired in resource-poor countries, because screening methods are technologically and financially intensive; affordable, reliable, and accurate methods are needed. We aimed to test the feasibility of implementing a sickle cell disease screening programme using innovative point-of-care test devices into existing immunisation programmes in primary health-care settings.MethodsBuilding on a routine immunisation programme and using existing facilities and staff, we did a prospective feasibility study at five primary health-care centres within Gwagwalada Area Council, Abuja, Nigeria. We systematically screened for sickle cell disease consecutive newborn babies and infants younger than 9 months who presented to immunisation clinics at these five centres, using an ELISA-based point-of care test (HemoTypeSC). A subgroup of consecutive babies who presented to immunisation clinics at the primary health-care centres, whose mothers gave consent, were tested by the HemoTypeSC point-of-care test alongside a different immunoassay-based point-of-care test (SickleSCAN) and the gold standard test, high-performance liquid chromatography (HPLC).FindingsBetween July 14, 2017, and Sept 3, 2019, 3603 newborn babies and infants who presented for immunisation were screened for sickle cell disease at five primary health-care centres using the ELISA-based point-of-care test. We identified 51 (1%) children with sickle cell anaemia (HbSS), four (<1%) heterozygous for HbS and HbC (HbSC), 740 (21%) with sickle cell trait (HbAS), 34 (1%) heterozygous for HbA and HbC (HbAC), and 2774 (77%) with normal haemoglobin (HbAA). Of the 55 babies and infants with confirmed sickle cell disease, 41 (75%) were e

    ImmunologieHématologiePédiatrieLicence : This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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  • Article libreArticleEn anglais

    Implementing the QUALI-DEC project in Argentina, Burkina Faso, Thailand and Viet Nam: a process delineation and theory-driven process evaluation protocol

    Amanda Cleeve, Kristi Sidney Annerstedt, Ana Pilar Betrán, Helle Mölsted Alvesson, Charles Kaboré Wendyam, Guillermo Carroli, Pisake Lumbiganon, Mac Quoc Nhu Hung, Karen Zamboni, Newton Opiyo, Meghan A. Bohren, Soha El Halabi, Celina Gialdini, Mercedes Vila Ortiz, Ramón Escuriet, Michael Robson, Alexandre Dumont, Claudia Hanson

    ABSTRACTThe project ‘Quality Decision-making by women and providers’ (QUALI-DEC) combines four non-clinical interventions to promote informed decision-making surrounding mode of birth, improve women’s birth experiences, and reduce caesarean sections among low-risk women. QUALI-DEC is currently being implemented in 32 healthcare facilities across Argentina, Burkina Faso, Thailand, and Viet Nam. In this paper, we detail implementation processes and the planned process evaluation, which aims to assess how and for whom QUALI-DEC worked, the mechanisms of change and their interactions with context and setting; adaptations to intervention and implementation strategies, feasibility of scaling-up, and cost-effectiveness of the intervention. We developed a project theory of change illustrating how QUALI-DEC might lead to impact. The theory of change, together with on the ground observations of implementation processes, guided the process evaluation strategy including what research questions and perspectives to prioritise. Main data sources will include: 1) regular monitoring visits in healthcare facilities, 2) quantitative process and output indicators, 3) a before and after cross-sectional survey among post-partum women, 4) qualitative interviews with all opinion leaders, and 5) qualitative interviews with postpartum women and health workers in two healthcare facilities per country, as part of a case study approach. We foresee that the QUALI-DEC process evaluation will generate valuable information that will improve interpretation of the effectiveness evaluation. At the policy level, we anticipate that important lessons and methodological insights will be drawn, with application to other settings and stakeholders looking to implement complex interventions aiming to improve maternal and newborn health and wellbeing.Trial registration: ISRCTN67214403.

    Biostatistiques et épidémiologieGynécologie-obstétriqueSanté publiqueLicence : http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this a
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  • Lien vers la sourceMémoire

    Implication de la méthylation de l’ADN dans l’adaptation locale de populations naturelles de chênes sessiles dans l’Ouest de l’Europe

    Romane Callarec

    Au regard de leur importance écologique et économique, la lutte contre le dépérissement des forêts en lien avec le réchauffement climatique est un enjeu scientifique et sociétal majeur. Sa rapidité pose notamment problème aux arbres, organismes sessiles et longévives, car ils peinent à s’y adapter. Ainsi, il est indispensable de mieux comprendre les mécanismes évolutifs permettant aux arbres de s’adapter à leurs environnements. Dans ce cadre, le rôle de l’épigénétique est prometteur puisque les marques épigénétiques peuvent évoluer rapidement sous l’effet de l’environnement, influencer fortement l’expression des gènes et être héritables sur plusieurs générations, trois caractéristiques requises pour l’adaptation rapide des populations. Dans ce contexte, nous avons étudié le rôle de la méthylation des cytosines (ou SMP) dans l’adaptation locale de 23 populations de chênes sessiles (Quercus petraea), une espèce clé de voûte des écosystèmes forestiers européens. Tout d’abord, nous n’avons pas observé de variation significative de la méthylation génomique entre populations. À l’échelle des locus, la variation des SMP discrimine néanmoins les provenances de Lappwald et de Serqueux. Cette variabilité et le fait que les individus échantillonnés aient été plantés en jardin commun suggèrent une probable héritabilité de ces méthylations. L’analyse de corrélation entre les 20 SMP discriminant le plus les populations et des variables climatiques a permis d’identifier 3 SMP co-variant avec les variables de température, de variation annuelle de température et d’humidité estivale. Ces associations sont notamment influencées par la localité de Vachères dont le climat mi-méditerranéen, mi-alpin très particulier est cohérent avec une possible adaptation locale de sa population.

    Biologie cellulaire et moléculaireGénétiqueLicence : https://creativecommons.org/licenses/by/4.0/
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  • Article libreArticle

    Implication des maris dans les soins anténatals: enquête sur les facilitateurs et les barrières: Cas des habitants de Bosomtwe au Ghana

    Anthony Kwame Morgan, Beatrice Aberinpoka Awafo, Theophilus Quartey, Justin Cobbold

    RésuméContexteCet article a abordé les facilitateurs et les obstacles relatifs à l’implication des maris dans les soins prénatals dans le district de Bosomtwe au Ghana, du point de vue des maris, des femmes enceintes avec et sans expérience d'accouchement, des mères allaitantes, des sage-femmes et des accoucheuses traditionnelles.MéthodologieL’étude s’est basée sur une conception de recherche qualitative pour recueillir et analyser les données sur les facilitateurs et les obstacles relatifs à l’implication des maris dans les soins prénatals. Le champ d’analyse était constitué de 36 participants, dont 14 maris, 8 femmes enceintes ayant déjà accouché et mères allaitantes, 6 femmes enceintes n’ayant jamais accouché, 6 sage-femmes et 2 accoucheuses traditionnelles—sélectionnés délibérément. Les données de l’étude ont été recueillies par le biais d'entretiens approfondis et analysées par l’approche du contexte.RésultatsNombreux facteurs empêchent la participation active des maris aux soins prénatals. Ces facteurs sont d’ordre économique (contraintes de temps), culturels (l’association de la maternité et ses obligations aux femmes) et le système de santé (manque de Services prénatals destinés aux maris et le comportement des personnels de santé). Malgré cela, certains maris ont participé aux soins prénatals en raison de l'importance qu'ils accordent à la santé et à la sécurité de leurs femmes et du fœtus, de l'évolution des rôles de chacun des sexes et des traitements préférentiels reçus par leurs femmes dans les maternités (en raison de la participation de leurs maris aux soins prénatals).ConclusionLa mise en œuvre des stratégies alternatives, telles que le conseil aux couples, la prolongation des heures d’ouverture des centres de santé pour accueillir les hommes fonctionnaires, est recommandée afin d'offrir aux maris un moyen plus souple et plus attrayant de soutenir leurs femmes pendant la grossesse. Ces efforts doivent être renforcés par tous dans la société en modifi

    Biostatistiques et épidémiologiePédiatrieGynécologie-obstétriqueLicence : Open Access http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/publicdomain/zero/1.0/ This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as
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    Implication du pharmacien d’officine dans le parcours de soins d’une arthroplastie de la hanche

    Violaine Poirel

    L’arthroplastie de la hanche permet à des milliers de patients chaque année en France de retrouver une mobilité articulaire sans douleur. Le parcours de soins de cette chirurgie est long et complexe et la durée d’hospitalisation de plus en plus courte. Le patient doit donc être accompagné au mieux pour son retour prompt à domicile en vue d’une récupération optimale. L’implication de tous les professionnels de santé à ses côtés est donc une nécessité, y compris celle du pharmacien d’officine qui se voit attribuer de plus en plus de missions au coeur de l’accompagnement du patient.

    PharmacologieToxicologiePharmacie galéniqueLicence : https://creativecommons.org/licenses/by/4.0/
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    Implication du pollen de canne à sucre dans les manifestations de la rhinite allergique: étude cas témoins

    Patrick Maholisoa Randrianandraina, Corinne Eulalie Solo, Ravaka Hariniaina Andriambelo, Mamy Jean Jacques Razafimahatratra, Heritsilavo Eloi Ramilison, Miora Christine Mamiharilala, Andriarimanana Hery Nirina Rakotoarisoa

    L´identification des allergènes est essentielle dans la prise en charge de la rhinite allergique. La canne à sucre produit un pollen anémophile. L´objectif de notre étude était de déterminer la place du pollen de canne à sucre dans la survenue de la rhinite allergique. Il s´agit d´une étude analytique type cas-témoins, menée de juillet 2017 à juin 2018, chez des patients habitants une commune rurale malgache dans laquelle la culture et le traitement de la canne à sucre constituent les principales occupations. Elle incluait 182 patients (91 cas et 91 témoins). Les facteurs associés à la survenue des signes de rhinite allergique étaient la distance de moins de 500 mètres entre les domiciles et les champs de canne à sucre (OR = 1,50), la profession exercée en contact direct avec la canne à sucre (OR=116) et la présence d´antécédent familial de rhinite allergique (OR=13,67). Par ailleurs, l´exposition aux rafales (OR=0,84) et la profession exercée en plein air (OR=0,92) étaient des facteurs protecteurs. L´exposition des patients au pollen de canne à sucre est associée aux manifestations cliniques de la rhinite allergique et confirme la place que tient cet allergène dans la survenue de ladite pathologie. Des mesures d´éviction et d´hygiènes constituent par conséquents la base du traitement.

    Licence : https://creativecommons.org/licenses/by/4.0/ The Pan African Medical Journal (ISSN: 1937-8688). This is an Open Access article distributed under the terms of the Creative Commons Attribution International 4.0 License (), which permits unrestricted use, distribution, and reproduction in any medium, p
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